TGF-β blockade significantly slows tumor growth through many mechanisms, including activation
of CD8 + T cells and macrophages. Here, we show that TGF-β blockade also increases …

Controversy surrounds neutrophil function in cancer because neutrophils were shown to
provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density …

Neutrophils play an established role in host defense and in killing invading microorganisms.
Although neutrophils are traditionally considered in the context of their antibacterial …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they act …

The role and importance of neutrophils in cancer has become increasingly apparent over
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer, …

The role of myeloid cells in supporting cancer growth is well established. Most work has focused
on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, …

Neutrophils are myeloid cells that constitute 50–70 % of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions have …

The mechanisms by which tumor‐associated neutrophils (TANs) affect tumor growth are to
a large extent unknown. Regulatory T‐cells (T‐regs) are functionally immune‐suppressive …

It is becoming increasingly clear that tumor-associated neutrophils (TANs) play an important
role in cancer biology, through direct impact on tumor growth and by recruitment of other …