Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b …

…, MR Sher, YP Li, WC Wu, ZJ Xu… - The Lancet …, 2020 - thelancet.com
Background Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment
of refractory and unexplained chronic cough. The aim of this study was to evaluate the …

[HTML][HTML] Safety and immunogenicity of the rVSV∆ G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind …

…, EJ Dasen, CJ Link, R Das, ZJ Xu… - The Lancet Infectious …, 2017 - thelancet.com
Background The 2014 Zaire Ebola virus outbreak highlighted the need for a safe, effective
vaccine with a rapid onset of protection. We report the safety and immunogenicity of the …

Gefapixant in two randomised dose-escalation studies in chronic cough

…, MM Kitt, P Butera, SA Smith, Y Li, ZJ Xu… - European …, 2020 - Eur Respiratory Soc
Background and objectives Gefapixant has previously demonstrated efficacy in the treatment
of refractory chronic cough at a high daily dose. The current investigations explore efficacy …

[HTML][HTML] Brief report: switching to DOR/3TC/TDF maintains HIV-1 virologic suppression through week 144 in the DRIVE-SHIFT trial

…, P Cahn, M Bickel, H Wan, ZJ Xu… - JAIDS Journal of …, 2021 - journals.lww.com
Background: In the primary analysis of the DRIVE-SHIFT trial, switching to doravirine/lamivudine/tenofovir
disoproxil fumarate (DOR/3TC/TDF) maintained suppression of HIV-1 through …

[HTML][HTML] Characterization of patients with refractory or unexplained chronic cough participating in a phase 2 clinical trial of the P2X3-receptor antagonist gefapixant

…, LP McGarvey, J Schelfhout, A Martin Nguyen, ZJ Xu… - Lung, 2021 - Springer
Purpose This analysis assesses clinical characteristics of patients with refractory chronic
cough (RCC) or unexplained chronic cough (UCC) enrolled in a phase 2 study to better …

[HTML][HTML] Steroids in the treatment of IgA nephropathy to the improvement of renal survival: a systematic review and meta-analysis

…, LG Tang, SL Guo, ZC Jin, MJ Wu, JJ Zang, JF Xu… - PloS one, 2011 - journals.plos.org
Background Studies have shown that steroids can improve kidney survival and decrease the
risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of …

A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features

C Jiehao, X Jin, L Daojiong, Y Zhi, X Lei… - Clinical Infectious …, 2020 - academic.oup.com
We first described the 2019 novel coronavirus infection in 10 children occurring in areas other
than Wuhan. The coronavirus diseases in children are usually mild and epidemiological …

Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells

N Blume, J Leonard, ZJ Xu, O Watanabe… - Archives of biochemistry …, 2000 - Elsevier
Endogenous steroids and numerous environmental agents have potent effects on mammary
development and carcinogenesis. Locally produced cytochrome P450 enzymes that modify …

Gradient fluorinated alloy to enable highly reversible Zn-metal anode chemistry

…, Z Chen, X Wang, B Xiong, J Fan, J Xu, C Zhi - Energy & …, 2022 - pubs.rsc.org
The unsatisfactory reversibility of zinc (Zn) metal anodes seriously hinders their wide practical
application. This corresponds to two major issues, namely the notorious dendrite growth …

Angiogenesis in pancreatic cancer: current research status and clinical implications

S Li, HX Xu, CT Wu, WQ Wang, W Jin, HL Gao, H Li… - Angiogenesis, 2019 - Springer
Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …