Airway eosinophils are increased in asthma and are especially abundant around airway
nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways …

Obesity affects more than 650 million adults worldwide and is a major risk factor for a variety
of serious comorbidities. The prevalence of obesity has tripled in the past forty years and …

Focal adhesion kinase (FAK) is a protein-tyrosine kinase that associates with multiple cell
surface receptors and signaling proteins through which it can modulate the activity of several …

Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis
in rodents. Here, we have determined the role of resistin in ob/ob mice that are obese and …

In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is
well established that eosinophils alter nerve function and that airway eosinophilia is present …

Eosinophils cluster around airway nerves in patients with fatal asthma and in antigen-challenged
animals. Activated eosinophils release major basic protein, which blocks inhibitory M2 …

Respiratory viruses cause asthma exacerbations. Because eosinophils are the prominent
leukocytes in the airways of 60–70% of patients with asthma, we evaluated the effects of …

Obesity is a substantial risk factor for developing asthma, but the molecular mechanisms
underlying this relationship are unclear. We tested the role of insulin in airway responsiveness …

Obesity increases incidence and severity of asthma but the molecular mechanisms are not
completely understood. Hyperinsulinemia potentiates vagally induced bronchoconstriction in …

Obesity-induced asthma responds poorly to all current pharmacological interventions,
including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism. Since …