Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …

Background Omalizumab, a humanized anti-IgE monoclonal antibody, is reportedly an
effective treatment for severe allergic asthma. However, there have been few comprehensive …

Rationale: Periostin is a matricellular protein that is involved in the pathophysiology of allergic
rhinitis, chronic rhinosinusitis, and asthma. Associations of serum periostin with systemic …

Background Although several computer-aided computed tomography (CT) analysis methods
have been reported to objectively assess the disease severity and progression of idiopathic …

Although longitudinal studies have demonstrated that subjects with asthma show a similar
degree of decline in pulmonary function compared with those without asthma (1, 2), a subset …

Background Asthmatic cough is often refractory to standard treatments such as inhaled
corticosteroids (ICS) and long-acting β 2 agonists (LABA). Tiotropium may modulate cough reflex …

Computed tomography (CT) assessment of the cross-sectional area of the erector spinae
muscles (ESM CSA ) can be used to evaluate sarcopenia and cachexia in patients with lung …

Background Comprehensive studies of the pathophysiologic characteristics of elderly
asthma, including predominant site of disease, airway inflammation profiles, and airway …

Background: Obesity affects the pathogenesis of various chronic diseases, including asthma.
Research on correlations between obesity/BMI and eosinophilic inflammation in asthma …

Background In steroid‐naive patients with asthma, several gene variants are associated
with a short‐term response to inhaled corticosteroid ( ICS ) treatment; this has mostly been …