[HTML][HTML] PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

M Bueno, YC Lai, Y Romero, J Brands… - The Journal of …, 2015 - Am Soc Clin Investig
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic
mechanisms that underlie the effects of advancing age remain largely unexplained. Some …

Pulmonary arterial hypertension: the clinical syndrome

YC Lai, KC Potoka, HC Champion, AL Mora… - Circulation …, 2014 - Am Heart Assoc
Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction
and vascular remodeling obstruct small pulmonary arteries, resulting in increased pulmonary …

SIRT3–AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure …

YC Lai, DM Tabima, JJ Dube, KS Hughan… - Circulation, 2016 - Am Heart Assoc
Background— Pulmonary hypertension associated with heart failure with preserved ejection
fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic …

Explore the possible effect of TiO2 and magnetic hematite nanoparticle addition on biohydrogen production by Clostridium pasteurianum based on gene expression …

PH Hsieh, YC Lai, KY Chen, CH Hung - International Journal of Hydrogen …, 2016 - Elsevier
Discussions on the positive effect of nano-sized metal addition to dark fermentation biohydrogen
production have been raised but the real stimulation mechanism remains unclear. In …

Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages

YC Lai, PS Tsai, CJ Huang - Journal of Surgical Research, 2009 - Elsevier
BACKGROUND: Effects of dexmedetomidine on regulating endotoxin-induced upregulation
of inflammatory molecules were elucidated. METHODS: Murine macrophages (RAW264.7 …

[HTML][HTML] Benchmarking of eight recurrent neural network variants for breath phase and adventitious sound detection on a self-developed open-access lung sound …

…, CC Chen, J Hsiao, CW Chen, LC Chen, YC Lai… - PLoS …, 2021 - journals.plos.org
A reliable, remote, and continuous real-time respiratory sound monitor with automated
respiratory sound analysis ability is urgently required in many clinical scenarios—such as in …

[HTML][HTML] Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

…, A Handen, G Speyer, S Kim, YC Lai… - The Journal of …, 2021 - Am Soc Clin Investig
The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH)
remains undefined. Cellular senescence is linked to PH with intracardiac shunts; however, its …

Degradation of polyurethane by bacterium isolated from soil and assessment of polyurethanolytic activity of a Pseudomonas putida strain

YH Peng, Y Shih, YC Lai, YZ Liu, YT Liu… - … Science and Pollution …, 2014 - Springer
The increasing usage and the persistence of polyester polyurethane (PU) generate
significant sources of environmental pollution. The effective and environmental friendly …

Metabolic Syndrome Mediates ROS-miR-193b-NFYA–Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary …

…, EA Goncharova, SY Chan, AC Straub, YC Lai… - Circulation, 2021 - Am Heart Assoc
Background: Many patients with heart failure with preserved ejection fraction have metabolic
syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in …

[HTML][HTML] The evaluation of microbiology and prognosis of Fournier's gangrene in past five years

LM Tang, YJ Su, YC Lai - Springerplus, 2015 - Springer
Objectives Fournier’s gangrene (FG) is an devastating disease that affects the perineum
and genitourinary region, and is commonly a result of poly-microbial infection. This study is …