[HTML][HTML] Autoimmunity in pulmonary arterial hypertension: evidence for local immunoglobulin production
T Shu, Y Xing, J Wang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a progressive life-threating disease. The notion
that autoimmunity is associated with PAH is widely recognized by the observations that …
that autoimmunity is associated with PAH is widely recognized by the observations that …
[HTML][HTML] Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration
…, H Hu, P Yang, B Li, X Song, J Pang, Y Xing… - … and Targeted Therapy, 2022 - nature.com
Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,
and currently used drugs cannot reverse the disease progress. Worse still, there are still …
and currently used drugs cannot reverse the disease progress. Worse still, there are still …
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE‐PAH
Y Xing, J Zhao, M Zhou, S Jing, X Zhao… - The FASEB …, 2021 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a common and fatal complication of systemic lupus
erythematosus (SLE). Whether the BMP receptor deficiency found in the genetic form of …
erythematosus (SLE). Whether the BMP receptor deficiency found in the genetic form of …
[HTML][HTML] Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA
…, Z Chen, J Li, Q Tang, W Lei, Y Xing… - European …, 2023 - Eur Respiratory Soc
Background Pulmonary hypertension (PH) is a life-threatening disease featuring pulmonary
vessel remodelling and perivascular inflammation. The effect, if any, of eosinophils (EOS) on …
vessel remodelling and perivascular inflammation. The effect, if any, of eosinophils (EOS) on …
CCL 11‐induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis
Y Xing, Y Tian, T Kurosawa, S Matsui, M Touma… - Genes to …, 2016 - Wiley Online Library
We previously demonstrated that IL ‐18 and CCL 11 were highly expressed in an NFSA tumor
cell line that showed limited angiogenesis and severe necrosis. However, IL ‐18 was not …
cell line that showed limited angiogenesis and severe necrosis. However, IL ‐18 was not …
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels
Y Xing, S Zhao, Q Wei, S Gong, X Zhao… - European …, 2018 - Eur Respiratory Soc
Genetic defects in bone morphogenetic protein type II receptor (BMPRII) signalling and
inflammation contribute to the pathogenesis of pulmonary arterial hypertension (PAH). The …
inflammation contribute to the pathogenesis of pulmonary arterial hypertension (PAH). The …
[HTML][HTML] miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a
L Qi, H Hongjuan, G Ning, H Zhengbin, X Yanjiang… - FEBS letters, 2013 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of
biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was …
biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was …
[HTML][HTML] Enhancement of phagocytosis and cytotoxicity in macrophages by tumor-derived IL-18 stimulation
X Henan, N Toyota, X Yanjiang, Y Fujita, H Zhijun… - BMB …, 2014 - ncbi.nlm.nih.gov
Inoculation of mice with the murine NFSA cell line caused the formation of large tumors with
necrotic tumor cores. FACS analysis revealed accumulations of CD11b+ cells in the tumors. …
necrotic tumor cores. FACS analysis revealed accumulations of CD11b+ cells in the tumors. …
Inhibition of blood vessel formation in tumors by IL‐18‐polarized M1 macrophages
Y Xing, Y Tian, T Kurosawa, S Matsui, M Touma… - Genes to …, 2016 - Wiley Online Library
We previously showed that interleukin ( IL )‐18 produced by NFSA cells induced the M1
type of macrophages in NFSA tumors, caused the destruction of endothelial cells in vitro and …
type of macrophages in NFSA tumors, caused the destruction of endothelial cells in vitro and …
Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension
…, J Pang, P Yang, R Gao, W Chen, C Yan, Y Xing… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Pulmonary hypertension (PH) is a progressive cardiopulmonary disease
with a high mortality rate. Although growing evidence has revealed the importance of …
with a high mortality rate. Although growing evidence has revealed the importance of …