Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease
…, AFG Antonis, YS Sabogal Piñeros… - The Journal of …, 2016 - Wiley Online Library
Human respiratory syncytial virus ( RSV ) is the most important cause of severe lower respiratory
tract disease ( LRTD ) in young children worldwide. Extensive neutrophil accumulation …
tract disease ( LRTD ) in young children worldwide. Extensive neutrophil accumulation …
Eosinophils capture viruses, a capacity that is defective in asthma
YS Sabogal Piñeros, SM Bal, A Dijkhuis, CJ Majoor… - Allergy, 2019 - Wiley Online Library
Background Activated eosinophils cause major pathology in stable and exacerbating asthma;
however, they can also display protective properties like an extracellular antiviral activity. …
however, they can also display protective properties like an extracellular antiviral activity. …
Anti–IL-5 in mild asthma alters rhinovirus-induced macrophage, B-cell, and neutrophil responses (MATERIAL). A placebo-controlled, double-blind study
YS Sabogal Piñeros, SM Bal… - American journal of …, 2019 - atsjournals.org
Rationale: Eosinophils drive pathophysiology in stable and exacerbating eosinophilic asthma,
and therefore treatment is focused on the reduction of eosinophil numbers. Mepolizumab, …
and therefore treatment is focused on the reduction of eosinophil numbers. Mepolizumab, …
[HTML][HTML] The dietary intake of carrot-derived rhamnogalacturonan-i accelerates and augments the innate immune and anti-viral interferon response to rhinovirus …
…, E Floris, S Lone-Latif, A Ravi, YS Sabogal Pineros… - Nutrients, 2021 - mdpi.com
Acute respiratory infections are an important health concern. Traditionally, polysaccharide-enriched
extracts from plants, containing immunomodulatory rhamnogalacturonan-I (RG-1), …
extracts from plants, containing immunomodulatory rhamnogalacturonan-I (RG-1), …
Phosphodiesterase 4 inhibitors attenuate virus‐induced activation of eosinophils from asthmatics without affecting virus binding
YS Sabogal Piñeros, T Dekker, B Smids… - Pharmacology …, 2020 - Wiley Online Library
Acute respiratory virus infections, such as influenza and RSV, are predominant causes of
asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they …
asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they …
Late breaking abstract-IL-33 drives influenza-induced exacerbations of asthma by halting anti-viral and Th1 responses
L Ravanetti, A Dijkhuis, YS Pineros, R Lutter - 2017 - Eur Respiratory Soc
Introduction: Influenza virus triggers severe exacerbations of asthma and IL-33 levels
correlate with the disease severity. We hypothesized that IL-33 is necessary to drive asthma …
correlate with the disease severity. We hypothesized that IL-33 is necessary to drive asthma …
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity
L Ravanetti, A Dijkhuis, T Dekker, YSS Pineros… - Journal of Allergy and …, 2019 - Elsevier
Background Influenza virus triggers severe asthma exacerbations for which no adequate
treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but its …
treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but its …
[HTML][HTML] Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty
…, T Dekker, M van Weeghel, YSS Piñeros… - Journal of Allergy and …, 2021 - Elsevier
… Dierdorp BSc b , Tamara Dekker BSc b , Michel van Weeghel PhD c , Yanaika S. Sabogal
Piñeros PhD a b , Pallav L. Shah MD, FRCP d e f , Nick HT ten Hacken MD, PhD g , Jouke T. …
Piñeros PhD a b , Pallav L. Shah MD, FRCP d e f , Nick HT ten Hacken MD, PhD g , Jouke T. …
Metabolic differences in bronchial epithelium from asthma patients and impact of bronchial thermoplasty
…, A Dijkhuis, B Dierdorp, T Dekker, YS Piñeros… - 2020 - Eur Respiratory Soc
Introduction: Bronchial epithelial cells (BECs) contribute to asthma pathophysiology. Does
the transcriptome of BECs reflect heterogeneity in inflammation, treatment response and …
the transcriptome of BECs reflect heterogeneity in inflammation, treatment response and …
LSC 2014 abstract-Influenza-induced exacerbation in a murine chronic house dust mite (HDM) asthma model
L Ravanetti, A Dijkhuis, YS Pineros… - European Respiratory …, 2014 - Eur Respiratory Soc
Introduction: Allergic asthma is a chronic inflammatory airways disease and viral airway
infections can cause acute worsening of asthma symptoms (exacerbation). The mechanisms that …
infections can cause acute worsening of asthma symptoms (exacerbation). The mechanisms that …