Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
T Sorsa, L Tjäderhane, YT Konttinen, A Lauhio… - Annals of …, 2006 - Taylor & Francis
Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions
both in the tissue destruction and immune responses related to periodontal inflammation. …
both in the tissue destruction and immune responses related to periodontal inflammation. …
Bone regeneration and stem cells
… YT Konttinen… YT Konttinen … YT Konttinen …
Recurrent aphthous ulcers today: a review of the growing knowledge
SS Natah, YT Konttinen, NS Enattah… - International journal of …, 2004 - Elsevier
Recurrent aphthous ulcers represent a very common but poorly understood mucosal disorder.
They occur in men and women of all ages, races and geographic regions. It is estimated …
They occur in men and women of all ages, races and geographic regions. It is estimated …
Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community
…, JR Kalden, L Kater, YT Konttinen… - … : Official Journal of …, 1993 - Wiley Online Library
Objective. Different sets of diagnostic criteria have been proposed for Sjögren's syndrome (SS),
but none have been validated with a large series of patients or in a multicenter study. We …
but none have been validated with a large series of patients or in a multicenter study. We …
Tumor targeting with a selective gelatinase inhibitor
…, C Kantor, CG Gahmberg, T Salo, YT Konttinen… - Nature …, 1999 - nature.com
Several lines of evidence suggest that tumor growth, angiogenesis, and metastasis are
dependent on matrix metalloproteinase (MMP) activity. However, the lack of inhibitors specific for …
dependent on matrix metalloproteinase (MMP) activity. However, the lack of inhibitors specific for …
[HTML][HTML] Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells: regulation by tumor necrosis factor-α and doxycycline
R Hanemaaijer, T Sorsa, YT Konttinen, Y Ding… - Journal of Biological …, 1997 - ASBMB
Neutrophil collagenase (matrix metalloproteinase-8 or MMP-8) is regarded as being
synthesized exclusively by polymorphonuclear neutrophils (PMN). However, in vivo MMP-8 …
synthesized exclusively by polymorphonuclear neutrophils (PMN). However, in vivo MMP-8 …
Assessment of the European classification criteria for Sjögren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. The …
…, R Gerli, PY Hatron, L Kater, YT Konttinen… - Annals of the …, 1996 - ard.bmj.com
OBJECTIVE: To assess the recently proposed preliminary criteria for the classification of
Sjögren's syndrome (SS) in a multicentre European study of a new series of clinically defined …
Sjögren's syndrome (SS) in a multicentre European study of a new series of clinically defined …
Regulation of macrophage activation
…, NE Miller, M Hukkanen, GF Ma, YT Konttinen - Cellular and Molecular …, 2003 - Springer
IFN-γ rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently
undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines …
undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines …
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis
YT Konttinen, M Ainola, H Valleala, J Ma… - Annals of the …, 1999 - ard.bmj.com
OBJECTIVE To define the pattern of mRNA expression of all human matrix metalloproteinases
(MMPs) described to date in rheumatoid arthritis (RA) and traumatic synovial membrane, …
(MMPs) described to date in rheumatoid arthritis (RA) and traumatic synovial membrane, …
Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients
…, A Haerian, DF Kinane, YT Konttinen… - Journal of clinical …, 1996 - Wiley Online Library
Matrix metalloproteinases (MMPs) and serine proteinases seem to be related to tissue
destruction in periodontitis. The presence of MMPs in gingival crevicular fluid (GCF) and saliva, …
destruction in periodontitis. The presence of MMPs in gingival crevicular fluid (GCF) and saliva, …