Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor
Palovarotene is an oral γ-selective retinoid agonist. In animal emphysema models, palovarotene
reduced inflammation, promoted structural repair and functional improvement. REPAIR (…
reduced inflammation, promoted structural repair and functional improvement. REPAIR (…
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation
…, JH Tashjian, EJR Beek, L Washington… - COPD: Journal of …, 2012 - Taylor & Francis
The purposes of this study were: to describe chest CT findings in normal non-smoking
controls and cigarette smokers with and without COPD; to compare the prevalence of CT …
controls and cigarette smokers with and without COPD; to compare the prevalence of CT …
Evaluation of outcomes: the effects of continuous lateral rotational therapy
GT Washington, CL Macnee - Journal of Nursing Care Quality, 2005 - journals.lww.com
Research on continuous lateral rotational therapy (CLRT) has demonstrated mixed results,
but there have been definite benefits described in its use for the prevention and treatment of …
but there have been definite benefits described in its use for the prevention and treatment of …
[HTML][HTML] Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura
The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an
asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. …
asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. …
[HTML][HTML] Airway dimensions in COPD: relationships with clinical variables
…, D McAllister, M Connell, JT Murchison, W MacNee - Respiratory …, 2010 - Elsevier
… defined as %WA = (outer area of airway – lumen area)/outer area of airway × 100. %WA was
… distal (3rd to 6th) and a mean %WA for each group calculated for analysis. This designation …
… distal (3rd to 6th) and a mean %WA for each group calculated for analysis. This designation …
Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease.
I Rahman, W MacNee - Thorax, 1996 - ncbi.nlm.nih.gov
… 4 Church T, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological …
20 Selby C, Drost E, Brown D, Howie S, MacNee W. Inhibition ofneutrophil adherence and …
20 Selby C, Drost E, Brown D, Howie S, MacNee W. Inhibition ofneutrophil adherence and …
[HTML][HTML] A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome highlights the challenges associated with draft genomes and gene prediction in …
…, M Wang, N Ileperuma, N Macnee… - BMC genomics, 2018 - Springer
Background Most published genome sequences are drafts, and most are dominated by
computational gene prediction. Draft genomes typically incorporate considerable sequence data …
computational gene prediction. Draft genomes typically incorporate considerable sequence data …
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles
The toxicology of nanoparticles (NPs) is an area of intense investigation that would be
greatly aided by improved understanding of the relationship between NP structure and …
greatly aided by improved understanding of the relationship between NP structure and …
Oxidative stress and regulation of glutathione in lung inflammation
I Rahman, W MacNee - European Respiratory Journal, 2000 - Eur Respiratory Soc
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …
Computed tomography-derived pathological phenotypes in COPD
W MacNee - European Respiratory Journal, 2016 - Eur Respiratory Soc
… WA%), an index less dependent on the airway size than wall area [25]. The second approach
that was developed to try and alleviate the error in the WA… However, WA% has been shown …
that was developed to try and alleviate the error in the WA… However, WA% has been shown …