Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor

…, EW Russi, DA Lomas, WA MacNee… - European …, 2012 - Eur Respiratory Soc
Palovarotene is an oral γ-selective retinoid agonist. In animal emphysema models, palovarotene
reduced inflammation, promoted structural repair and functional improvement. REPAIR (…

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

…, JH Tashjian, EJR Beek, L Washington… - COPD: Journal of …, 2012 - Taylor & Francis
The purposes of this study were: to describe chest CT findings in normal non-smoking
controls and cigarette smokers with and without COPD; to compare the prevalence of CT …

Evaluation of outcomes: the effects of continuous lateral rotational therapy

GT Washington, CL Macnee - Journal of Nursing Care Quality, 2005 - journals.lww.com
Research on continuous lateral rotational therapy (CLRT) has demonstrated mixed results,
but there have been definite benefits described in its use for the prevention and treatment of …

[HTML][HTML] Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura

…, A Bianco, M Prato, W MacNee, WA Wallace… - The American journal of …, 2011 - Elsevier
The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an
asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. …

[HTML][HTML] Airway dimensions in COPD: relationships with clinical variables

…, D McAllister, M Connell, JT Murchison, W MacNee - Respiratory …, 2010 - Elsevier
… defined as %WA = (outer area of airway – lumen area)/outer area of airway × 100. %WA was
… distal (3rd to 6th) and a mean %WA for each group calculated for analysis. This designation …

Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease.

I Rahman, W MacNee - Thorax, 1996 - ncbi.nlm.nih.gov
… 4 Church T, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological …
20 Selby C, Drost E, Brown D, Howie S, MacNee W. Inhibition ofneutrophil adherence and …

[HTML][HTML] A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome highlights the challenges associated with draft genomes and gene prediction in …

…, M Wang, N Ileperuma, N Macnee… - BMC genomics, 2018 - Springer
Background Most published genome sequences are drafts, and most are dominated by
computational gene prediction. Draft genomes typically incorporate considerable sequence data …

Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles

…, M Bradley, IL Megson, W MacNee… - Toxicological …, 2012 - academic.oup.com
The toxicology of nanoparticles (NPs) is an area of intense investigation that would be
greatly aided by improved understanding of the relationship between NP structure and …

Oxidative stress and regulation of glutathione in lung inflammation

I Rahman, W MacNee - European Respiratory Journal, 2000 - Eur Respiratory Soc
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …

Computed tomography-derived pathological phenotypes in COPD

W MacNee - European Respiratory Journal, 2016 - Eur Respiratory Soc
WA%), an index less dependent on the airway size than wall area [25]. The second approach
that was developed to try and alleviate the error in the WA… However, WA% has been shown …