Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily
in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity…

To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated
human saphenous vein endothelial cells with several NO donors and assessed …

The crucial role played by the myofibroblast in wound healing and pathological organ
remodeling is well established; the general mechanisms of extracellular matrix synthesis and of …

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, …

Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive and …

Members of the NADPH oxidase (NOX) family of enzymes, which catalyze the reduction of
O 2 to reactive oxygen species, have increased in number during eukaryotic evolution 1 , 2 . …

Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the recruitment, …

Myofibroblast differentiation and activation by transforming growth factor-ॆ1 (TGF-ॆ1) is a
critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for …

The incidence and prevalence of pathological fibrosis increase with advancing age, although
mechanisms for this association are unclear. We assessed the capacity for repair of lung …

Myofibroblasts accumulate in the spaces between organ structures and produce extracellular
matrix (ECM) proteins, including collagen I. They are the primary “effector” cells in tissue …