User profiles for Valerie Urbach
 | Valerie Urbach PhD HDRINSERM, France Verified email at inserm.fr Cited by 1838 |
[HTML][HTML] Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
…, I Pranke, B Villeret, CH Cottart, JP Vrel, V Urbach… - Scientific reports, 2019 - nature.com
Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells
…, NVT Quynh, R Chiron, V Urbach - American Journal of …, 2009 - journals.physiology.org
Lipoxin A 4 (LXA 4 ) is a biologically active eicosanoid produced in human airways that displays
anti-inflammatory properties. In cystic fibrosis and severe asthma, LXA 4 production has …
anti-inflammatory properties. In cystic fibrosis and severe asthma, LXA 4 production has …
[HTML][HTML] Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
…, D Grenet, M Thumerel, J Mazenq, V Urbach… - Scientific reports, 2017 - nature.com
Clinical studies with modulators of the Cystic Fibrosis Transmembrane conductance Regulator
(CFTR) protein have demonstrated that functional restoration of the mutated CFTR can …
(CFTR) protein have demonstrated that functional restoration of the mutated CFTR can …
Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics
…, V Escabasse, B Louis, V Urbach - Proceedings of the …, 2024 - National Acad Sciences
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation.
However, cilia beating features in a CF altered environment, consisting of dehydrated …
However, cilia beating features in a CF altered environment, consisting of dehydrated …
[HTML][HTML] Lipoxin A4 Stimulates Calcium-Activated Chloride Currents and Increases Airway Surface Liquid Height in Normal and Cystic Fibrosis Airway Epithelia
Cystic Fibrosis (CF) is a genetic disease characterised by a deficit in epithelial Cl − secretion
which in the lung leads to airway dehydration and a reduced Airway Surface Liquid (ASL) …
which in the lung leads to airway dehydration and a reduced Airway Surface Liquid (ASL) …
Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis
Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A 4 (LXA 4 ) initiates the …
persistent bacterial infection and neutrophilic inflammation. Lipoxin A 4 (LXA 4 ) initiates the …
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor-γ (PPARγ)
ligands that are widely used in type II diabetes treatment. In addition to their ability to …
ligands that are widely used in type II diabetes treatment. In addition to their ability to …
Rapid non‐genomic inhibition of ATP‐induced Cl− secretion by dexamethasone in human bronchial epithelium
V Urbach, DE Walsh, B Mainprice… - The Journal of …, 2002 - Wiley Online Library
A non‐genomic antisecretory role for dexamethasone at low concentrations (0.1 nm to1 μm)
is described in monolayers of human bronchial epithelial cells in primary culture and in a …
is described in monolayers of human bronchial epithelial cells in primary culture and in a …
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels
…, V Bustos, R Rapetti‐Mauss, V Urbach… - The Journal of …, 2011 - Wiley Online Library
Non‐Technical Summary High levels of oestrogen are known to cause fluid retention in
fertile females. It is thought that the increase in body fluid volume is necessary for proper …
fertile females. It is thought that the increase in body fluid volume is necessary for proper …
[HTML][HTML] Might brushed nasal cells be a surrogate for CFTR modulator clinical response?
…, F Chedevergne, C Bailly, V Urbach… - American journal of …, 2019 - atsjournals.org
Results HNE cell cultures were obtained from 18 patients. HNE cells did not show a significant
CFTR-dependent Cl− secretion at basal state. After incubation with VX-809, the mean …
CFTR-dependent Cl− secretion at basal state. After incubation with VX-809, the mean …