Rationale: Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by
telomere shortening or oxidative stress may contribute to pulmonary hypertension associated …

Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH)
may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The …

Background— Induction of cellular senescence through activation of the p53 tumor suppressor
protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin …

Pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation are key
components of pulmonary arterial hypertension (PAH). Interleukin (IL)-1β binds to IL-1 receptor (R…

Monocytes/macrophages are major effectors of lung inflammation associated with various
forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/…

Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).
To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (…

Background Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute
respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects …

Tight regulation of the balance between apoptosis and survival is essential in angiogenesis.
The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition …

Rationale: Chronic obstructive pulmonary disease (COPD) is associated with chronic
inflammation of unknown pathogenesis. Objectives: To investigate whether telomere dysfunction …

Background— Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying
diseases such as HIV infection, results from complex vessel remodeling involving both …