Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease
…, E Marcos, M Saker, N Vienney, V Amsellem… - Circulation …, 2011 - Am Heart Assoc
Rationale: Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by
telomere shortening or oxidative stress may contribute to pulmonary hypertension associated …
telomere shortening or oxidative stress may contribute to pulmonary hypertension associated …
Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
…, CM Tissot, JL Dubois-Randé, V Amsellem… - American journal of …, 2013 - atsjournals.org
Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH)
may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The …
may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The …
Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension
…, L Boyer, J Boczkowski, G Derumeaux, V Amsellem… - Circulation, 2013 - Am Heart Assoc
Background— Induction of cellular senescence through activation of the p53 tumor suppressor
protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin …
protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin …
Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension
A Parpaleix, V Amsellem, A Houssaini… - European …, 2016 - Eur Respiratory Soc
Pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation are key
components of pulmonary arterial hypertension (PAH). Interleukin (IL)-1β binds to IL-1 receptor (R…
components of pulmonary arterial hypertension (PAH). Interleukin (IL)-1β binds to IL-1 receptor (R…
Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine systems in hypoxic pulmonary hypertension
Monocytes/macrophages are major effectors of lung inflammation associated with various
forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/…
forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/…
CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension
…, E Marcos, A Parpaleix, V Amsellem… - European …, 2019 - Eur Respiratory Soc
Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).
To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (…
To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (…
[HTML][HTML] Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury
G Voiriot, K Razazi, V Amsellem, J Tran Van Nhieu… - Respiratory …, 2017 - Springer
Background Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute
respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects …
respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects …
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
GM Birdsey, NH Dryden, V Amsellem… - Blood, The Journal …, 2008 - ashpublications.org
Tight regulation of the balance between apoptosis and survival is essential in angiogenesis.
The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition …
The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition …
Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease
V Amsellem, G Gary-Bobo, E Marcos… - American journal of …, 2011 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with chronic
inflammation of unknown pathogenesis. Objectives: To investigate whether telomere dysfunction …
inflammation of unknown pathogenesis. Objectives: To investigate whether telomere dysfunction …
CCR5 as a treatment target in pulmonary arterial hypertension
Background— Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying
diseases such as HIV infection, results from complex vessel remodeling involving both …
diseases such as HIV infection, results from complex vessel remodeling involving both …