The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
RA Cardone, V Casavola, SJ Reshkin - Nature reviews cancer, 2005 - nature.com
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …
Na+/H+ exchanger‐dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent …
…, M Poignee, M Alunni‐Fabbroni, V Casavola… - The FASEB …, 2000 - Wiley Online Library
In this study we investigate the mechanism of intracellular pH change and its role in
malignant transformation using the E7 oncogene of human papillomavirus type 16 (HPV16). …
malignant transformation using the E7 oncogene of human papillomavirus type 16 (HPV16). …
NHE1 promotes invadopodial ECM proteolysis through acidification of the peri‐invadopodial space
…, MT Mancini, ME Dell'Aquila, V Casavola… - The FASEB …, 2010 - Wiley Online Library
Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires
membrane and released proteases focalized at membrane structures called invadopodia. …
membrane and released proteases focalized at membrane structures called invadopodia. …
[HTML][HTML] Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na+/H+ exchange, motility, and invasion induced by serum …
…, M Tommasino, A Paradiso, V Casavola - Journal of Biological …, 2000 - ASBMB
Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the
mechanism(s) behind this acidification, especially in low nutrient conditions, are unclear. The …
mechanism(s) behind this acidification, especially in low nutrient conditions, are unclear. The …
The NHERF1 PDZ2 domain regulates PKA–RhoA–p38-mediated NHE1 activation and invasion in breast tumor cells
…, EJ Weinman, ME Dell'Aquila, V Casavola… - Molecular biology of …, 2007 - Am Soc Cell Biol
Understanding the signal transduction systems governing invasion is fundamental for the
design of therapeutic strategies against metastasis. Na + /H + exchanger regulatory factor (…
design of therapeutic strategies against metastasis. Na + /H + exchanger regulatory factor (…
Paclitaxel Induces Apoptosis via Protein Kinase A- and p38 Mitogen-activated Protein-dependent Inhibition of the Na+/H+ Exchanger (NHE) NHE Isoform 1 in …
…, A Bellizzi, RA Cardone, M Tommasino, V Casavola… - Clinical cancer …, 2003 - AACR
Purpose: The molecular signal components essential to paclitaxel-dependent apoptosis in
breast cancers are potential targets for combined therapy. However, the signal mechanisms …
breast cancers are potential targets for combined therapy. However, the signal mechanisms …
[HTML][HTML] Goblet cell hyperplasia requires high bicarbonate transport to support mucin release
…, A Gianotti, I Musante, M Favia, V Casavola… - Scientific reports, 2016 - nature.com
Goblet cell hyperplasia, a feature of asthma and other respiratory diseases, is driven by the
Th-2 cytokines IL-4 and IL-13. In human bronchial epithelial cells, we find that IL-4 induces …
Th-2 cytokines IL-4 and IL-13. In human bronchial epithelial cells, we find that IL-4 induces …
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines
…, L Guerra, A Paradiso, V Casavola… - Molecular biology of …, 2005 - Am Soc Cell Biol
Metastasis results from a sequence of selective events often involving interactions with elements
of the tumor-specific physiological microenvironment. The low-serum component of this …
of the tumor-specific physiological microenvironment. The low-serum component of this …
CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity
…, D Marzulli, SJ Reshkin, V Casavola… - Journal of cell …, 2012 - journals.biologists.com
The cystic fibrosis transmembrane conductance regulator (CFTR) mutation ΔF508CFTR still
causes regulatory defects when rescued to the apical membrane, suggesting that the …
causes regulatory defects when rescued to the apical membrane, suggesting that the …
[HTML][HTML] Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity …
…, SJ Reshkin, M Conese, V Casavola - Journal of Biological …, 2005 - ASBMB
There is evidence that cystic fibrosis transmembrane conductance regulator (CFTR) interacting
proteins play critical roles in the proper expression and function of CFTR. The Na + /H + …
proteins play critical roles in the proper expression and function of CFTR. The Na + /H + …