[HTML][HTML] PCSK9 induces tissue factor expression by activation of TLR4/NFkB signaling

V Scalise, C Sanguinetti, T Neri, S Cianchetti… - International Journal of …, 2021 - mdpi.com
Proprotein convertase subtilisin kexin 9 (PCSK9) increases LDL cholesterol (C)
concentration by accelerating the hepatic degradation of the LDL receptor (R) thus promoting …

Particulate matter induces prothrombotic microparticle shedding by human mononuclear and endothelial cells

…, L Pergoli, S Petrini, L Gravendonk, C Balia, V Scalise… - Toxicology In Vitro, 2016 - Elsevier
Particulate airborne pollution is associated with increased cardiopulmonary morbidity.
Microparticles are extracellular vesicles shed by cells upon activation or apoptosis involved in …

[HTML][HTML] Carpal tunnel syndrome: a national survey to monitor knowledge and operating methods

V Scalise, F Brindisino, L Pellicciari, S Minnucci… - International Journal of …, 2021 - mdpi.com
The aim of this article was to investigate the knowledge, management, and clinical practice
of Italian physiotherapists concerning patients with carpal tunnel syndrome (CTS). A national …

[HTML][HTML] Binding of gamma-glutamyl transferase to TLR4 signalling allows tissue factor activation in monocytes

C Sanguinetti, V Scalise, T Neri, A Celi… - International Journal of …, 2022 - mdpi.com
Gamma-glutamyl transferase (GGT) is involved in the progression of atherosclerosis, since
its enzymatic activity promotes the generation of reactive oxygen species (ROS). Besides, …

Pirfenidone inhibits p38-mediated generation of procoagulant microparticles by human alveolar epithelial cells

…, F Faìta, S Petrini, C Balìa, V Scalise… - Pulmonary …, 2016 - Elsevier
Pirfenidone is a drug recently approved for idiopathic pulmonary fibrosis but its mechanisms
of action are partially unknown. We have previously demonstrated that the airways of …

Leptin induces the generation of procoagulant, tissue factor bearing microparticles by human peripheral blood mononuclear cells

…, S Lombardi, C Cordazzo, C Balìa, V Scalise… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Obesity is linked to increased thrombotic risk. Circulating leptin concentration
correlates with body mass index. Microparticles are small (.05–1 μm) vesicles shed by …

[HTML][HTML] A novel prothrombotic role of proprotein convertase subtilisin kexin 9: the generation of procoagulant extracellular vesicles by human mononuclear cells

V Scalise, S Lombardi, C Sanguinetti, D Nieri… - Molecular Biology …, 2022 - Springer
Background Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized
mainly in the liver that binds the receptor of low-density lipoprotein and promotes its …

CD18-mediated adhesion is required for the induction of a proinflammatory phenotype in lung epithelial cells by mononuclear cell-derived extracellular vesicles

T Neri, V Scalise, I Passalacqua, I Giusti… - Experimental Cell …, 2018 - Elsevier
Extracellular vesicles are submicron vesicles that upregulate the synthesis of proinflammatory
mediators by lung epithelial cells. We investigated whether these structures adhere to …

[HTML][HTML] Tiotropium inhibits proinflammatory microparticle generation by human bronchial and endothelial cells

T Neri, V Scalise, I Passalacqua, C Sanguinetti… - Scientific Reports, 2019 - nature.com
Tiotropium is a muscarinic antagonist that reduces the risk of acute exacerbations of chronic
obstructive pulmonary disease, possibly through an as yet incompletely characterized anti-…

[HTML][HTML] miR-19a and miR-20a and tissue factor expression in activated human peripheral blood mononuclear cells

C Balia, M Giordano, V Scalise, T Neri, G Fontanini… - Thrombosis, 2017 - hindawi.com
Background and Aims. To investigate the behaviour of miR-19a and miR-20a, two
microRNAs involved in posttranscriptional modulation of TF expression in peripheral blood …