The human early-life exposome (HELIX): project rationale and design

…, E Sabidó, PE Schwarze, V Siroux… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Developmental periods in early life may be particularly vulnerable to impacts
of environmental exposures. Human research on this topic has generally focused on single …

MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

…, S Reitamo, E Rial‐Sebbag, M Salapatas, V Siroux… - Allergy, 2011 - Wiley Online Library
To cite this article: Bousquet J, Anto J, Auffray C, Akdis M, Cambon‐Thomsen A, Keil T, Haahtela
T, Lambrecht BN, Postma DS, Sunyer J, Valenta R, Akdis CA, Annesi‐Maesano I, Arno …

Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

…, E Rial-Sebbag, Y Saeys, MJ Schuijs, V Siroux… - Journal of Allergy and …, 2017 - Elsevier
… Onset was also found to occur earlier than in mono sensitized individuals or in those with
asthma or rhinitis and no IgE sensitization (Siroux, personal communication). …

Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma

V Siroux, I Pin, MP Oryszczyn… - European …, 2000 - Eur Respiratory Soc
The role of smoking as potential risk factor, selection factor ("healthy smoker" effect) and
modifying factor (severity) of asthma was studied in the Epidemiological study on the Genetics …

[HTML][HTML] Effect of 17q21 variants and smoking exposure in early-onset asthma

…, N Le Moual, P Scheinmann, V Siroux… - New England journal …, 2008 - Mass Medical Soc
Background A genomewide association study has shown an association between variants
at chromosome 17q21 and an increased risk of asthma. To elucidate the relationship …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

…, PA Selivanova, T Sigsgaard, A Simpson, V Siroux… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

…, D Sugiri, Z Al Kanani, R Nadif, V Siroux… - European respiratory …, 2015 - Eur Respiratory Soc
The chronic impact of ambient air pollutants on lung function in adults is not fully understood.
The objective of this study was to investigate the association of long-term exposure to …

Identifying adult asthma phenotypes using a clustering approach

V Siroux, X Basagaña, A Boudier, I Pin… - European …, 2011 - Eur Respiratory Soc
There is a need to improve asthma characterisation by integrating multiple aspects of the
disease. The aim of the present study was to identify distinct asthma phenotypes by applying …

Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)

B Jacquemin, V Siroux, M Sanchez… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Short-term exposure to air pollution has adverse effects among patients with
asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is …

Asthma severity is associated with body mass index and early menarche in women

R Varraso, V Siroux, J Maccario, I Pin… - American journal of …, 2005 - atsjournals.org
Asthma severity in relation to body mass index (BMI) has rarely been studied. The relation
between BMI and asthma severity was studied by sex in 366 adults with asthma from the …