Interplay between microRNAs and the epigenetic machinery: an intricate network

MV Iorio, C Piovan, CM Croce - Biochimica et Biophysica Acta (BBA)-Gene …, 2010 - Elsevier
microRNAs take their place into the epigenetic world revealing a complicated network of
reciprocal interconnections: not only they are able to control gene expression at a post-…

Breast cancer and microRNAs: therapeutic impact

MV Iorio, P Casalini, C Piovan, L Braccioli, E Tagliabue - The Breast, 2011 - Elsevier
Despite advances in detection and therapies, breast cancer is still the leading cause of cancer
death in women worldwide. The etiology of this neoplasm is complex, and both genetic …

[HTML][HTML] Aberrant signaling pathways in T-cell acute lymphoblastic leukemia

D Bongiovanni, V Saccomani, E Piovan - International journal of …, 2017 - mdpi.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant
transformation of immature progenitors primed towards T-cell development. Clinically, T-…

microRNA-205 regulates HER3 in human breast cancer

MV Iorio, P Casalini, C Piovan, G Di Leva, A Merlo… - Cancer research, 2009 - AACR
An increasing amount of experimental evidence shows that microRNAs can have a causal
role in breast cancer tumorigenesis as a novel class of oncogenes or tumor suppressor genes…

MicroRNA cluster 221-222 and estrogen receptor α interactions in breast cancer

G Di Leva, P Gasparini, C Piovan… - JNCI: Journal of the …, 2010 - academic.oup.com
Background Several lines of evidence have suggested that estrogen receptor α (ERα)–negative
breast tumors, which are highly aggressive and nonresponsive to hormonal therapy, …

[PDF][PDF] Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

E Piovan, J Yu, V Tosello, D Herranz… - Cancer cell, 2013 - cell.com
Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic
leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the …

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

M Saito, U Novak, E Piovan, K Basso… - Proceedings of the …, 2009 - National Acad Sciences
The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal
center (GC) formation and whose deregulation by genomic lesions is implicated in the …

The ITER full size plasma source device design

…, S Peruzzo, A Pesce, N Pilan, R Piovan… - Fusion Engineering and …, 2009 - Elsevier
In the framework of the strategy for the development and the procurement of the NB systems
for ITER, it has been decided to build in Padova a test facility, including two experimental …

[HTML][HTML] Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer

C Piovan, D Palmieri, G Di Leva, L Braccioli… - Molecular …, 2012 - Elsevier
An increasing body of evidence highlights an intriguing interaction between microRNAs and
transcriptional factors involved in determining cell fate, including the well known “genome …

[HTML][HTML] Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status

G Di Leva, C Piovan, P Gasparini, A Ngankeu… - PLoS …, 2013 - journals.plos.org
MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological
processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions …