The nerve growth factor (NGF) belongs to the neurotrophin family and induces its effects
through activation of 2 distinct receptor types: the tropomyosin-related kinase A (TrkA) receptor, …

Mitochondria are essential cell organelles responsible for ATP production in the presence of
oxygen. In the pulmonary vasculature, mitochondria contribute to physiological intracellular …

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a
general or respiratory physician. Treatment options are limited and one meta-analysis …

Pulmonary hypertension (PH) is characterized by a progressive elevation of pulmonary
arterial pressure due to alterations of both pulmonary vascular structure and function. This …

Rationale Severe pulmonary hypertension (PH) is very uncommon in COPD, and a distinct
phenotype has been hypothesised. We aimed to evaluate whether CT can help to recognise …

A variety of cell types in pulmonary arteries (endothelial cells, fibroblasts, and smooth
muscle cells) are continuously exposed to mechanical stimulations such as shear stress and …

In intrapulmonary arteries (IPAs), mechanical forces due to blood flow control vessel tone,
and these forces change during pulmonary hypertension (PH). Piezo1, a stretch-activated …

Background and purpose: Sensory nerves regulate central and local reflexes such as airway
plasma protein leakage, bronchoconstriction and cough. Sensory nerve activity may be …

Rationale: Pulmonary hypertension (PH) is characterized by a progressive elevation in
mean pulmonary arterial pressure, often leading to right ventricular failure and death. Growth …

Connexins are transmembrane proteins that can generate intercellular communication
channels known as gap junctions. They contribute to the direct movement of ions and larger …