“Chemistry has become a mature science, with all the advantages and handicaps of maturity:
harvest is abundant, but many people think future and adventure are to be found elsewhere…

A number of intrinsic and extrinsic mutagens induce structural damage in cellular DNA. These
DNA damages are cytotoxic, miscoding or both and are believed to be at the origin of cell …

… Boyd and L Gross, unpublished). The proposed mechanism predicts a loss of 2~ whereas
cyclization after oxidation would give a 20Da loss. Measured time constants for the oxidative …

Background There is considerable interest in the role of different candidate loci in the
development of asthma. This study investigates the association between asthma severity and …

Seven of 14 C3H mice inoculated when less than 12 hours old with Ak leukemic extracts
developed leukemia at 8 to 11 months of age. 2. Four of 6 C3H mice inoculated. when less than …

Background The stem cell factor receptor, KIT, is a target for the treatment of cancer,
mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo profiles of …

Immune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers
are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting …

Background Imatinib treatment significantly improves survival in patients with chronic myeloid
leukaemia (CML), but little is known about whether treatment can safely be discontinued in …

… Douglass Cater and Stephen Strickland wrote a book on the report and argued for “ongoing
research capable of undergirding large public policy investigations” (l,p.l33). And, finally, a …

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a
DNA glycosylase‐independent manner, providing the correct ends for DNA synthesis coupled …