Most UK hospitals, laboratories, and research institutions use uniform reference intervals (RI)
that do not take into account known diurnal and racial variation in total white blood cells (…

Aims Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart
failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific …

Aims Food is known to shorten the QT c ( QT c I and QT c F ) interval and has been proposed
as a non‐pharmacological method of confirming assay sensitivity in thorough QT ( TQT ) …

Concentration-effect (CE) models applied to early clinical QT data from healthy subjects are
described in the latest E14 Q&A document as promising analysis to characterise QTc …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Drugs that inhibit the human cardiac
delayed rectifier potassium current may lead to prolongation of the cardiac QT interval and …

Background and Aims Take‐home naloxone can prevent death from heroin/opioid overdose,
but pre‐provision is difficult because naloxone is usually given by injection. Non‐injectable …

This article attempts to define terminology and to describe a process for writing adaptive, early
phase study protocols which are transparent, self-intuitive and uniform. It provides a step …

Background and objectives In the rare disease primary hyperoxaluria type 1, overproduction
of oxalate by the liver causes kidney stones, nephrocalcinosis, kidney failure, and systemic …

MMV390048 is a novel antimalarial compound that inhibits Plasmodium
phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial …

Aim The D 2 /D 3 antagonist amisulpride has shown promising efficacy against postoperative
nausea and vomiting (PONV) at low doses. We investigated whether intravenous …