Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

… T-cell stimulation and possibly actions on regulatory T (T Reg ) cells 125 (in this article T Reg
cells are defined as CD4 + CD25 + T cells … Ipilimumab has been shown to cause T-cell and …

Rationale: Accumulation of eosinophils in the bronchial mucosa of individuals with asthma
is considered to be a central event in the pathogenesis of asthma. In animal models, airway …

Activation of lymphocyte subpopulations was determined in conjunction with levels of cytokines
in peripheral blood and bronchoalveolar lavage (BAL) of asthmatics. Allergic asthmatics …

A simple method is described for the isolation of human peripheral blood eosinophils by an
immunomagnetic procedure. Superparamagnetic particles were coupled to a monoclonal …

Background Interleukin-12 (IL-12) is a macrophage-derived cytokine that modulates T
lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. …

The evidence base for the benefit of quitting smoking as regards morbidity and mortality
outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) is …

Immunological activation of mast cells is an important trigger in the cascade of inflammatory
events leading to the manifestation of allergic diseases. Pharmacological studies using the …

… Correspondence and requests for reprints should be addressed to Trevor T. Hansel, FRCPath.,
Ph.D., NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 …

Increasing evidence suggests an important role for cytokines in the regulation of
eosinophilic inflammation. In the present study we investigated the distribution of leukocytes, …