User profiles for Tillie-Louise Hackett
 | Tillie L HackettProfessor, Department of Anesthesiology, Pharmacology, Therapeutics, University of British … Verified email at hli.ubc.ca Cited by 8701 |
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
…, A Tam, T Shaipanich, TL Hackett… - European …, 2020 - Eur Respiratory Soc
The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19)
a pandemic [1]. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (…
a pandemic [1]. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (…
Induction of epithelial–mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1
Rationale: Airway remodeling in asthma is associated with the accumulation of fibroblasts,
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
The contribution of small airway obstruction to the pathogenesis of chronic obstructive pulmonary disease
The hypothesis that the small conducting airways were the major site of obstruction to airflow
in normal lungs was introduced by Rohrer in 1915 and prevailed until Weibel introduced a …
in normal lungs was introduced by Rohrer in 1915 and prevailed until Weibel introduced a …
Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution
TL Hackett, GK Singhera, F Shaheen… - American journal of …, 2011 - atsjournals.org
A substantial proportion of healthcare cost associated with asthma is attributable to exacerbations
of the disease. Within the airway, the epithelium forms the mucosal immune barrier, …
of the disease. Within the airway, the epithelium forms the mucosal immune barrier, …
Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study
Background The concept that small conducting airways less than 2 mm in diameter become
the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD) is well …
the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD) is well …
Epithelial–mesenchymal transition in the pathophysiology of airway remodelling in asthma
TL Hackett - Current opinion in allergy and clinical immunology, 2012 - journals.lww.com
It is becoming increasingly clear that the airway epithelium orchestrates inflammatory and
remodeling responses of the airway. Understanding the regulatory mechanisms involved in …
remodeling responses of the airway. Understanding the regulatory mechanisms involved in …
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
BACKGROUND: The airway epithelium is the first line of defense against inhaled insults and
therefore must be capable of coordinating appropriate inflammatory and immune responses…
therefore must be capable of coordinating appropriate inflammatory and immune responses…
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
…, M Van den Berge, TL Hackett… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke…
personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke…
[HTML][HTML] Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)
We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis
through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and an …
through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and an …
[HTML][HTML] Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study
TL Hackett, R Holloway, ST Holgate, JA Warner - Respiratory research, 2008 - Springer
Background Exacerbations of Chronic obstructive pulmonary disease (COPD) are an important
cause of the morbidity and mortality associated with the disease. Strategies to reduce …
cause of the morbidity and mortality associated with the disease. Strategies to reduce …