Continuous versus intermittent infusion of vancomycin in severe staphylococcal infections: prospective multicenter randomized study

…, F Thomas, JF Timsit, T Similowski… - Antimicrobial agents …, 2001 - Am Soc Microbiol
A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in
severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections. A multicenter, …

Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial

…, S Parer-Aubas, F Stéphan, T Similowski… - Annals of internal …, 2000 - acpjournals.org
Background: Optimal management of patients who are clinically suspected of having
ventilator-associated pneumonia remains open to debate. Objective: To evaluate the effect on …

Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy

A Chambellan, E Chailleux, T Similowski - Chest, 2005 - Elsevier
Background Although traditionally associated with polycythemia, COPD has a systemic
inflammatory component that could interfere with erythropoiesis. This study describes the …

Low rate of daily smokers in patients with symptomatic COVID-19

…, E Caumes, P Hausfater, A Combes, T Similowski… - MedRxiv, 2020 - medrxiv.org
Background Identification of prognostic factors in COVID-19 remains a global challenge.
The role of smoking is still controversial. Objective To evaluate the rate of daily smokers in …

Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans

…, M Sebbane, T Similowski… - American journal of …, 2011 - atsjournals.org
Rationale: Diaphragmatic function is a major determinant of the ability to successfully wean
patients from mechanical ventilation (MV). Paradoxically, MV itself results in a rapid loss of …

[HTML][HTML] Contractile properties of the human diaphragm during chronic hyperinflation

T Similowski, S Yan, AP Gauthier… - … England Journal of …, 1991 - Mass Medical Soc
Background. In patients with chronic obstructive pulmonary disease (COPD) and hyperinflation
of the lungs, dysfunction of the diaphragm may contribute to respiratory decompensation. …

ERS statement on respiratory muscle testing at rest and during exercise

…, A Rossi, F Series, T Similowski… - European …, 2019 - Eur Respiratory Soc
Assessing respiratory mechanics and muscle function is critical for both clinical practice and
research purposes. Several methodological developments over the past two decades have …

Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact—a prospective study

…, S Matecki, A Duguet, T Similowski… - American journal of …, 2013 - atsjournals.org
Rationale: Diaphragmatic insults occurring during intensive care unit (ICU) stays have become
the focus of intense research. However, diaphragmatic abnormalities at the initial phase …

Coexistence and impact of limb muscle and diaphragm weakness at time of liberation from mechanical ventilation in medical intensive care unit patients

…, D Reuter, L Brochard, T Similowski… - American journal of …, 2017 - atsjournals.org
Rationale: Intensive care unit (ICU)- and mechanical ventilation (MV)-acquired limb muscle
and diaphragm dysfunction may both be associated with longer length of stay and worse …

[HTML][HTML] Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients

F Blot, T Similowski, JL Trouillet, P Chardon… - Intensive care …, 2008 - Springer
Objective Although several advantages are attributed to tracheotomy in ICU patients requiring
mechanical ventilation (MV), true benefits and the optimal timing of tracheotomy remain …