Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality …

Background Biomarkers can be used to detect the presence of endothelial and/or alveolar
epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion …

Background Rhinovirus infection is a major cause of asthma exacerbations. Objectives We
studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-…

INTRODUCTION Even with intimate exposure to a virus, some people fail to become infected.
Variable transmission partly depends on the dose and duration of exposure but is also …

Rationale: Respiratory syncytial virus (RSV) bronchiolitis is a major cause of morbidity and
mortality in infancy. Severe disease is believed to result from uncontrolled viral replication, an …

Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms
underlying susceptibility are poorly understood. Here, we identify that obese individuals have …

The methods of nasal absorption (NA) and bronchial absorption (BA) use synthetic absorptive
matrices (SAM) to absorb the mucosal lining fluid (MLF) of the human respiratory tract. NA …

Background Acute respiratory viral infections are a major cause of respiratory morbidity and
mortality, especially in patients with preexisting lung diseases such as asthma. Toll-like …

Background Patients with asthma are at risk of hospitalisation with influenza, but the reasons
for this predisposition are unknown. Study setting A prospective observational study of …

Background. Existing respiratory mucosal sampling methods are flawed, particularly in a
pediatric bronchiolitis setting. Methods. Twenty-four infants with bronchiolitis were recruited: 12 …