[HTML][HTML] Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells
No methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human
embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been …
embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been …
Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
…, Y Nakano, T Oguma, S Hozawa, T Nagasaki… - Journal of allergy and …, 2013 - Elsevier
Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …
[PDF][PDF] Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells
…, K Tateishi, Y Yamamoto, Y Korogi, T Nagasaki… - Stem cell reports, 2016 - cell.com
Multi-ciliated airway cells (MCACs) play a role in mucociliary clearance of the lung. However,
the efficient induction of functional MCACs from human pluripotent stem cells has not yet …
the efficient induction of functional MCACs from human pluripotent stem cells has not yet …
Long-term expansion of alveolar stem cells derived from human iPS cells in organoids
…, M Seki, S Konishi, S Ikeo, N Sone, T Nagasaki… - Nature …, 2017 - nature.com
The stable expansion of tissue-specific stem cells in vitro has contributed to research on several
organs. Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung, but …
organs. Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung, but …
[HTML][HTML] DOCK2 is involved in the host genetics and biology of severe COVID-19
…, T Sado, Y Miyazaki, R Sato, Y Haruta, T Nagasaki… - Nature, 2022 - nature.com
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1
, 2 , 3 , 4 – 5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 …
, 2 , 3 , 4 – 5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 …
[HTML][HTML] 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
T Nagasaki, AJ Schuyler, J Zhao… - The Journal of …, 2022 - Am Soc Clin Investig
Altered redox biology challenges all cells, with compensatory responses often determining
a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in …
a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in …
Influences of smoking and aging on allergic airway inflammation in asthma
T Nagasaki, H Matsumoto - Allergology International, 2013 - Elsevier
Asthma is a heterogeneous disease with varying phenotypes and numerous risk factors.
This condition results from complex interactions between genetic and environmental factors, …
This condition results from complex interactions between genetic and environmental factors, …
Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study
…, H Nakaji, H Inoue, T Iwata, T Nagasaki… - Annals of Allergy …, 2014 - Elsevier
Background Omalizumab, a humanized anti-IgE monoclonal antibody, is reportedly an
effective treatment for severe allergic asthma. However, there have been few comprehensive …
effective treatment for severe allergic asthma. However, there have been few comprehensive …
[PDF][PDF] In vitro disease modeling of Hermansky-Pudlak syndrome type 2 using human induced pluripotent stem cell-derived alveolar organoids
…, Y Yamamoto, N Sone, K Tamai, S Konishi, T Nagasaki… - Stem cell reports, 2019 - cell.com
It has been challenging to generate in vitro models of alveolar lung diseases, as the stable
culture of alveolar type 2 (AT2) cells has been difficult. Methods of generating and expanding …
culture of alveolar type 2 (AT2) cells has been difficult. Methods of generating and expanding …
PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells
…, E Etling, JC Rosenbaum, T Nagasaki… - Proceedings of the …, 2020 - National Acad Sciences
Temporally harmonized elimination of damaged or unnecessary organelles and cells is a
prerequisite of health. Under Type 2 inflammatory conditions, human airway epithelial cells (…
prerequisite of health. Under Type 2 inflammatory conditions, human airway epithelial cells (…