BACKGROUND Since the 1998 European Respiratory Society (ERS) lower respiratory tract
infection (LRTI) guidelines 1 were published, the evidence on which they were based has …

Background Antibiotic use and concomitant resistance are increasing. Literature reviews do
not unambiguously indicate which interventions are most effective in improving antibiotic …

Randomised allocation of vaccine or placebo is the preferred method to assess the effects of
the vaccine on clinical outcomes relevant to the individual patient. In the absence of phase …

Guidelines for the management of adult lower respiratory tract infections â•’ Full version Page
1 Guidelines for the management of adult lower respiratory tract infections - Full version M. …

Background Pneumococcal polysaccharide conjugate vaccines prevent pneumococcal
disease in infants, but their efficacy against pneumococcal community-acquired pneumonia in …

Objective: To determine the effect of antibiotic treatment for acute otitis media in children
between 6 months and 2 years of age. Design: Practice based, double blind, randomised, …

Objectives To quantify the diagnostic accuracy of selected inflammatory markers in addition
to symptoms and signs for predicting pneumonia and to derive a diagnostic tool. Design …

Background and objective: Indicators to measure the quality of healthcare are increasingly
used by healthcare professionals and policy makers. In the context of increasing antimicrobial …

… of the trial, and statistical analyses; KGM Moons did statistical analyses; GA van Essen
recruited family doctors; RJ Stolker recruited anaesthetists; and CJ Kalkman and TJM Verheij co-…

Background. Numerous studies suggest overprescribing of antibiotics for respiratory tract
indications (RTIs), without really authenticating inappropriate prescription; the strict criteria of …