Creation and application of virtual patient cohorts of heart models

…, S Coveney, EM Cherry, T Delhaas… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

Optic nerve sheath diameter assessment by neurosonology: a review of methodologic discrepancies

…, M Ertl, WH Mess, W Huberts, T Delhaas - Journal of …, 2021 - Wiley Online Library
Background and Purpose Reported cutoff values of the optic nerve sheath diameter (ONSD)
for the diagnosis of elevated intracranial pressure (ICP) are inconsistent. This hampers …

The 'Digital Twin'to enable the vision of precision cardiology

…, R Cornelussen, F Prinzen, T Delhaas… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position paper…

Satellite cells in human skeletal muscle; from birth to old age

LB Verdijk, T Snijders, M Drost, T Delhaas, F Kadi… - Age, 2014 - Springer
… by paired samples t tests in the young adult, older, and senescent groups separately. … In
case of significant interaction, paired samples t tests were performed to assess changes over …

Pediatric pulmonary hypertension in the Netherlands: epidemiology and characterization during the period 1991 to 2005

…, ADJ ten Harkel, M van Osch-Gevers, T Delhaas… - Circulation, 2011 - Am Heart Assoc
Background— Incidence and prevalence rates for pediatric pulmonary hypertension (PH) and
pulmonary arterial hypertension (PAH) are unknown. This study describes the nationwide …

Anatomic relationship of the complex tricuspid valve, right ventricle, and pulmonary vasculature: a review

RT Hahn, AB Waxman, P Denti, T Delhaas - JAMA cardiology, 2019 - jamanetwork.com
Importance Severe functional or secondary tricuspid regurgitation (TR) is associated with
poor long-term outcomes in natural history studies as well as specific disease states. An …

Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia

…, P Andriessen, T Delhaas… - Stem cells …, 2016 - academic.oup.com
… Finally, we assessed the influx of T lymphocytes in the fetal brain by immunohistochemical
analysis for CD3 in the SCWM (Fig. 6). Cerebral influx of CD3-positive cells tended to …

Asymmetric thickness of the left ventricular wall resulting from asynchronous electric activation: a study in dogs with ventricular pacing and in patients with left bundle …

…, T Delhaas, MFM van Oosterhout, T Arts… - American heart …, 1995 - Elsevier
Various kinds of abnormal, asynchronous electric activation of the left ventricle (LV) decrease
mechanical load in early versus late activated regions of the ventricular wall. Because …

Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model

T Arts, T Delhaas, P Bovendeerd… - American Journal …, 2005 - journals.physiology.org
… The function fRise(t/t rise ) represents a smooth positive unity amplitude pulse with
duration proportional to t rise . For the active stress component, it was used as follows …

Cardiac resynchronisation therapy in paediatric and congenital heart disease: differential effects in various anatomical and functional substrates

…, JR Jacobsen, F van den Heuvel, T Delhaas… - Heart, 2009 - heart.bmj.com
… one-way analysis of variance, two-tailed t test or Mann–Whitney rank sum test, as appropriate.
Paired comparisons were performed by paired t test. Predictors of improvement in systolic …