Health hazards due to the inhalation of amorphous silica

…, S Philippou, H Bauer, R Breitstadt, T Bruening - Archives of …, 2002 - Springer
Occupational exposure to crystalline silica dust is associated with an increased risk for
pulmonary diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive …

Assessing exposure to phthalates–the human biomonitoring approach

…, HM Koch, J Angerer, T Brüning - Molecular nutrition & …, 2011 - Wiley Online Library
Some phthalates are developmental and reproductive toxicants in animals. Exposure to
phthalates is considered to be potentially harmful to human health as well. Based on a …

[HTML][HTML] Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics

…, U Hamann, YD Ko, T Bruening, S Haas, T Dörk… - PLoS …, 2008 - journals.plos.org
A three-stage genome-wide association study recently identified single nucleotide
polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat …

Health effects due to endotoxin inhalation

V Liebers, M Raulf-Heimsoth, T Brüning - Archives of toxicology, 2008 - Springer
Endotoxins are ubiquitous in the environment and represent important components of
bioaerosols. High exposure occurs in rural environment and at several workplaces (eg waste …

Association analysis identifies 65 new breast cancer risk loci

…, A Broeks, A Brooks-Wilson, SY Brucker, T Brüning… - Nature, 2017 - nature.com
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

…, M Grip, H Brauch, U Hamann, T Brüning… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

[PDF][PDF] Polygenic risk scores for prediction of breast cancer and breast cancer subtypes

…, A Brooks-Wilson, SY Brucker, T Brüning… - The American Journal of …, 2019 - cell.com
Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

…, U Hamann, B Pesch, T Brüning… - Journal of the …, 2011 - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …

[HTML][HTML] Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers

…, N Ulrich, EM Marek, J Bünger, T Brüning… - Particle and Fibre …, 2018 - Springer
Background Inhalation of high concentrations of zinc oxide particles (ZnO) may cause metal
fume fever. In an earlier human inhalation study, no effects were observed after exposure to …

Prediction of breast cancer risk based on profiling with common genetic variants

…, MC Southey, H Brauch, T Brüning… - Journal of the …, 2015 - academic.oup.com
Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …