User profiles for Sune F. Nielsen

Sune Fallgaard Nielsen

Scientist at Herlev Hospital, Copenhagen University Hospital
Verified email at regionh.dk
Cited by 21963

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

…, K Humphreys, J Li, BG Nordestgaard, SF Nielsen… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

…, MS Geybels, BG Nordestgaard, SF Nielsen… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

…, P Klarskov, BG Nordestgaard, MA Røder, SF Nielsen… - Nature …, 2013 - nature.com
Prostate cancer is the most frequently diagnosed cancer in males in developed countries.
To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Prediction of breast cancer risk based on profiling with common genetic variants

…, BG Nordestgaard, SF Nielsen… - Journal of the …, 2015 - academic.oup.com
Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

…, SE Bojesen, BG Nordestgaard, H Flyger, SF Nielsen… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) and large-scale replication studies have identified
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

…, JD French, X Chen, M Weischer, SF Nielsen… - Nature …, 2013 - nature.com
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …

Exome-wide association study of plasma lipids in> 300,000 individuals

…, PB Munroe, MJ Neville, JB Nielsen, SF Nielsen… - Nature …, 2017 - nature.com
We screened variants on an exome-focused genotyping array in> 300,000 participants (replication
in> 280,000 participants) and identified 444 independent variants in 250 loci …

[HTML][HTML] Statin use and reduced cancer-related mortality

SF Nielsen, BG Nordestgaard… - New England Journal of …, 2012 - Mass Medical Soc
Background A reduction in the availability of cholesterol may limit the cellular proliferation
required for cancer growth and metastasis. We tested the hypothesis that statin use begun …

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

…, FC Hamdy, RM Martin, BG Nordestgaard, SF Nielsen… - Nature …, 2021 - nature.com
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

…, J Erdmann, BG Nordestgaard, SF Nielsen… - Science, 2016 - science.org
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower …