The p16 INK4a (p16) tumor suppressor gene can be inactivated by promoter region
hypermethylation in many tumor types including lung cancer, the leading cause of cancer-related …

Despite the promise of using DNA markers for the early detection of cancer, none has proven
universally applicable to the most common and lethal forms of human malignancy. Lung …

Lung cancer is the leading cause of cancer deaths worldwide, yet few genetic markers of
lung cancer risk useful for screening exist. The let-7 family-of-microRNAs (miRNA) are global …

Background Despite optimal and early surgical treatment of non–small-cell lung cancer (NSCLC),
many patients die of recurrent NSCLC. We investigated the association between gene …

Epigenetic alterations are strongly associated with the development of cancer. We conducted
a phase I/II trial of combined epigenetic therapy with azacitidine and entinostat, inhibitors …

Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial
component in cancer initiation and progression. Highly sensitive assays have been developed …

Recent studies from our laboratory suggest that gene-specific methylation changes in sputum
could be good intermediate markers for the early detection of lung cancer and defining the …

A sensitive screening approach for lung cancer could markedly reduce the high mortality
rate for this disease. Previous studies have shown that methylation of gene promoters is …

We have developed a technique, methylation-specific PCR in situ hybridization (MSP-ISH),
which allows for the methylation status of specific DNA sequences to be visualized in …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …