Diabetic nephropathy (DN) remains an unmet medical challenge as its prevalence is
projected to continue to increase and specific medicines for treatment remain undeveloped. …

Objective Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and
differentiation of human adipose precursor cells and prevents the browning effect of BMP4…

Diabetic Nephropathy (DN) remains an unmet medical challenge as its prevalence is
projected to continue to increase and specific medicines for treatment remain undeveloped. …

Rationale: To investigate house dust mite (HDM) induced airway inflammation we developed
a single lung challenge mouse model and stimulated alveolar macrophages ex vivo. Dectin…

Progressive loss of renal function is mostly observed in diabetic and hypertensive patients.
Activation of the immune system, in particular T-cells, is emerging as a possible mechanism …

Introduction: How the immune system senses aeroallergens and triggers an aberrant
inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern …

Early Xenopus embryos are large, and during the egg to gastrula stages, when there is little
extracellular matrix, the cytoskeletons of the individual blastomeres are thought to maintain …

The control of cytoarchitecture is fundamentally important in multicellular organisms, both
for tissue assembly during embryonic development and for adult tissue remodeling. The …

Developmental biology teachers use the example of the frog embryo to introduce young
scientists to the wonders of vertebrate development, and to pose the crucial question, `How …

Background Epithelial damage, repair and remodelling are critical features of chronic
airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 …