Leptin and leptin receptor expression in asthma

…, G Chiappara, M La Guardia, S Gerbino… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: The adipokine leptin is a potential new mediator for bronchial epithelial
homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling …

Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line

A Bruno, L Siena, S Gerbino, M Ferraro… - European Journal of …, 2011 - Elsevier
Background Apigenin, a common edible plant flavonoid, is a well characterised antioxidant.
The adipokine leptin exerts proliferative and anti-apoptotic activities in a variety of cell types. …

Oxidative stress and innate immunity responses in cigarette smoke stimulated nasal epithelial cells

E Pace, M Ferraro, S Di Vincenzo, S Gerbino, A Bruno… - Toxicology in Vitro, 2014 - Elsevier
Cigarette smoke extracts (CSE) may play a significant role in diseases of the upper airway
including chronic rhinosinusitis. Even short term exposure of cigarette smoke has adverse …

Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells

…, S Di Vincenzo, C Cipollina, S Gerbino… - Cell Stress and …, 2013 - Springer
Cigarette smoke extracts (CSE) induce oxidative stress, an important feature in chronic
obstructive pulmonary disease (COPD), and oxidative stress contributes to the poor clinical …

Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide-and cigarette smoke-induced …

C Cipollina, S Di Vincenzo, S Gerbino, L Siena… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background 17-Oxo-DHA is an endogenous electrophilic derivative of the omega-3 fatty acid
docosahexaenoic acid (DHA) which is generated in activated macrophages by the action …

Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells

E Pace, M Ferraro, L Siena, V Scafidi, S Gerbino… - Toxicology letters, 2013 - Elsevier
Cigarette smoke represents the major risk factor for chronic obstructive pulmonary disease (COPD).
Cigarette smoke extracts (CSE) alter TLR4 expression and activation in bronchial …

In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD.

…, A Bonanno, M Ferraro, GD Albano, S Gerbino… - …, 2011 - europepmc.org
Novel pharmacological strategies are aimed at the resolution of systemic inflammation in
COPD potentiating peripheral blood T-cell (PBT-cell) apoptosis. Although muscarinic …

[HTML][HTML] Effects in cigarette smoke stimulated bronchial epithelial cells of a corticosteroid entrapped into nanostructured lipid carriers

ML Bondì, M Ferraro, S Di Vincenzo, S Gerbino… - Journal of …, 2014 - Springer
Background Nanomedicine studies have showed a great potential for drug delivery into the
lung. In this manuscript nanostructured lipid carriers (NLC) containing Fluticasone …

Fluticasone furoate maintains epithelial homeostasis via leptin/leptin receptor pathway in nasal cells

A Bruno, S Gerbino, M Ferraro, L Siena… - Molecular and cellular …, 2014 - Springer
Leptin is involved in the lung epithelial homeostasis. Its role in the nasal tract is largely
unknown. Allergic rhinitis (AR) is induced by the allergen exposure leading to consequential …