[HTML][HTML] Triple Therapy for Cystic Fibrosis Phe508del–Gating and –Residual Function Genotypes
…, EF McKone, BW Ramsey, S Sutharsan… - … England Journal of …, 2021 - Mass Medical Soc
Background Elexacaftor–tezacaftor–ivacaftor is a small-molecule cystic fibrosis transmembrane
conductance regulator (CFTR) modulator regimen shown to be efficacious in patients …
conductance regulator (CFTR) modulator regimen shown to be efficacious in patients …
Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week …
Background Elexacaftor plus tezacaftor plus ivacaftor is a triple-combination cystic fibrosis
transmembrane conductance regulator (CFTR) modulator regimen shown to be generally safe …
transmembrane conductance regulator (CFTR) modulator regimen shown to be generally safe …
[HTML][HTML] ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19
…, K Schmidt, S Skrzypczyk, S Sutharsan… - Pharmacogenetics …, 2021 - journals.lww.com
Objectives The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is responsible for coronavirus disease 2019 (COVID-19). Cell entry is mediated by the …
is responsible for coronavirus disease 2019 (COVID-19). Cell entry is mediated by the …
[HTML][HTML] Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case …
…, F Herbstreit, J Risse, K Schmidt, S Sutharsan… - Frontiers in …, 2021 - frontiersin.org
The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables
entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host …
entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host …
[HTML][HTML] Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials
…, D Willey-Courand, C Schwarz, S Sutharsan… - The Lancet …, 2023 - thelancet.com
Background Elexacaftor–tezacaftor–ivacaftor has been shown to be safe and efficacious in
people with cystic fibrosis and at least one F508del allele. Our aim was to identify a novel …
people with cystic fibrosis and at least one F508del allele. Our aim was to identify a novel …
[HTML][HTML] Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus
…, A Schuster, FK Tegtmeyer, S Sutharsan… - PloS one, 2016 - journals.plos.org
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF).
However, it is not clear which factors are associated with worse lung function in patients with …
However, it is not clear which factors are associated with worse lung function in patients with …
SPEF2- and HYDIN-Mutant Cilia Lack the Central Pair–associated Protein SPEF2, Aiding Primary Ciliary Dyskinesia Diagnostics
…, JK Marthin, KG Nielsen, S Sutharsan… - American journal of …, 2020 - atsjournals.org
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous chronic destructive airway
disease. PCD is traditionally diagnosed by nasal nitric oxide measurement, analysis of ciliary …
disease. PCD is traditionally diagnosed by nasal nitric oxide measurement, analysis of ciliary …
Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del …
…, F Stehling, A Hector, S Sutharsan… - The Lancet …, 2021 - thelancet.com
Background Tezacaftor–ivacaftor is an approved cystic fibrosis transmembrane conductance
regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated …
regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated …
The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19
…, F Herbstreit, J Risse, K Schmidt, S Sutharsan… - Cytokine, 2021 - Elsevier
Background and aims The interferon-induced transmembrane protein 3 (IFITM3) plays an
important role in the adaptive and innate immune response by inhibiting viral membrane …
important role in the adaptive and innate immune response by inhibiting viral membrane …
Prevalence and characterization of azole-resistant Aspergillus fumigatus in patients with cystic fibrosis: a prospective multicentre study in Germany
…, A Essig, F Stehling, S Sutharsan… - Journal of …, 2018 - academic.oup.com
Objectives Aspergillus fumigatus is the most prevalent filamentous fungus in the respiratory
tract of patients with cystic fibrosis (CF). The aim of this prospective multicentre study was to …
tract of patients with cystic fibrosis (CF). The aim of this prospective multicentre study was to …