[HTML][HTML] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
M Yoshida, S Minagawa, J Araya, T Sakamoto… - Nature …, 2019 - nature.com
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis …
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis …
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
S Minagawa, J Araya, T Numata… - … of Physiology-Lung …, 2011 - journals.physiology.org
Reepithelialization of remodeled air spaces with bronchial epithelial cells is a prominent
pathological finding in idiopathic pulmonary fibrosis (IPF) and is implicated in IPF pathogenesis. …
pathological finding in idiopathic pulmonary fibrosis (IPF) and is implicated in IPF pathogenesis. …
PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
…, N Takasaka, M Yoshida, H Hara, S Minagawa… - Autophagy, 2015 - Taylor & Francis
Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species
(ROS) production has been implicated in COPD pathogenesis by accelerating senescence…
(ROS) production has been implicated in COPD pathogenesis by accelerating senescence…
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
…, N Takasaka, J Kojima, S Ito, S Minagawa… - …, 2012 - Taylor & Francis
Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by …
of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by …
[HTML][HTML] Metformin attenuates lung fibrosis development via NOX4 suppression
…, N Takasaka, M Yoshida, K Tsubouchi, S Minagawa… - Respiratory …, 2016 - Springer
Background Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial
process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, …
process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, …
[HTML][HTML] Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β
…, S Somanath, T Barker, S Minagawa… - The Journal of …, 2011 - Am Soc Clin Investig
The airway is a primary portal of entry for noxious environmental stimuli that can trigger
airway remodeling, which contributes significantly to airway obstruction in chronic obstructive …
airway remodeling, which contributes significantly to airway obstruction in chronic obstructive …
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
…, Y Yoshii, Y Yumino, S Fujii, S Minagawa… - The Journal of …, 2014 - journals.aai.org
Cigarette smoke (CS)–induced cellular senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …
Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)
K Kuwano, J Araya, H Hara, S Minagawa… - Respiratory …, 2016 - Elsevier
Aging is associated with impairments in homeostasis. Although aging and senescence are
not equivalent, the number of senescent cells increases with aging. Cellular senescence …
not equivalent, the number of senescent cells increases with aging. Cellular senescence …
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis
J Araya, K Tsubouchi, N Sato, S Ito, S Minagawa… - Autophagy, 2019 - Taylor & Francis
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a …
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a …
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk
…, S Fujimoto, H Kawamoto, S Minagawa… - Journal of …, 2021 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …