Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant …

…, I Kalandadze, S Gogishvili… - Clinical Infectious …, 2012 - academic.oup.com
The pathogenesis of increasing drug resistance among patients with multidrug-resistant or
extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing …

Lung tissue concentrations of pyrazinamide among patients with drug-resistant pulmonary tuberculosis

…, I Sabulua, N Bablishvili, S Gogishvili… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help
optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing …

Favorable outcomes for multidrug and extensively drug resistant tuberculosis patients undergoing surgery

S Vashakidze, S Gogishvili, K Nikolaishvili… - The Annals of thoracic …, 2013 - Elsevier
BACKGROUND: New approaches are needed in the treatment of multidrug-resistant and
extensively drug-resistant pulmonary tuberculosis (M/XDR-PTB). We evaluated the role of …

[HTML][HTML] Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis

…, JA Kempker, NA Jakobia, SG Gogishvili… - International Journal of …, 2019 - Elsevier
Background Post-treatment morbidity among subjects with drug-resistant tuberculosis (DR-TB)
is unclear. Methods This was a cross-sectional study of patients from Tbilisi, Georgia with …

Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis

…, N Tukvadze, N Bablishvili, S Gogishvili… - Antimicrobial agents …, 2015 - Am Soc Microbiol
A better understanding of second-line drug (SLD) pharmacokinetics, including cavitary
penetration, may help optimize SLD dosing. Patients with pulmonary multidrug-resistant …

[HTML][HTML] Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia

S Vashakidze, A Despuig, S Gogishvili… - International Journal of …, 2017 - Elsevier
Objectives Our aim was to retrospectively compare clinical data and characteristics of removed
lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. …

Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study

…, N Tukvadze, N Bablishvili, S Gogishvili… - Journal of …, 2018 - academic.oup.com
Background Moxifloxacin is a second-line anti-TB drug that is useful in the treatment of drug-resistant
TB. However, little is known about its target site pharmacokinetics. Lower drug …

[HTML][HTML] Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

…, M Martín-Céspedes, S Vashakidze, S Gogishvili… - Mucosal …, 2020 - Elsevier
Modulation of immunity and disease by glycans is increasingly recognized. However, how
host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We …

Impact of adjuvant therapeutic surgery on the health-related quality of life of pulmonary tuberculosis patients

P Benito, S Vashakidze, S Gogishvili… - ERJ Open …, 2020 - Eur Respiratory Soc
This study aimed to determine the health-related quality of life (HRQoL) of patients with
pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In …

A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis

…, I Sabulua, N Bablishvili, S Gogishvili… - European …, 2018 - Eur Respiratory Soc
Linezolid has become a frequent component of treatment regimens for drug-resistant tuberculosis
and is a group C drug in the latest World Health Organization treatment guidelines [1]. …