User profiles for Shivraj Yabaji
 | Shivraj M. YabajiPostdoctoral Associate Verified email at bu.edu Cited by 139 |
[PDF][PDF] Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
Macrophages contribute to host immunity and tissue homeostasis via alternative activation
programs. M1-like macrophages control intracellular bacterial pathogens and tumor …
programs. M1-like macrophages control intracellular bacterial pathogens and tumor …
ESAT-6 regulates autophagous response through SOD-2 and as a result induces intracellular survival of Mycobacterium bovis BCG
Mycobacterium is known for subverting the host defense machinery, and one such
mechanism is the inhibition of autophagy. Here, we have demonstrated that Mycobacterium …
mechanism is the inhibition of autophagy. Here, we have demonstrated that Mycobacterium …
An update on COVID-19: SARS-CoV-2 life cycle, immunopathology, and BCG vaccination
The causative agent of novel coronavirus disease (COVID-19) is severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 possesses RNA as a genetic …
syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 possesses RNA as a genetic …
Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK
Early secretory antigenic target protein (ESAT-6) is an important virulent factor which plays
a crucial role in Mycobacterium tuberculosis (MTB) pathogenesis. Here, we demonstrate the …
a crucial role in Mycobacterium tuberculosis (MTB) pathogenesis. Here, we demonstrate the …
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages
Understanding cell state transitions and purposefully controlling them to improve therapies
is a longstanding challenge in biological research and medicine. Here, we identify a …
is a longstanding challenge in biological research and medicine. Here, we identify a …
Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas
Tuberculosis remains a critical infectious disease world-wide. The development of novel
therapeutic strategies requires greater understanding of host factors that contribute to disease …
therapeutic strategies requires greater understanding of host factors that contribute to disease …
[HTML][HTML] Progression and dissemination of pulmonary Mycobacterium avium infection in a susceptible immunocompetent mouse model
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM),
Mycobacterium avium complex (MAC), are a growing public health concern with incidence and …
Mycobacterium avium complex (MAC), are a growing public health concern with incidence and …
ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase (PtpA) has so far been
known to control intracellular survival of mycobacteria; whereas the ATP synthase which is …
known to control intracellular survival of mycobacteria; whereas the ATP synthase which is …
Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation
The remarkable ability of Mycobacterium tuberculosis (Mtb) to survive inside human
macrophages is attributed to the presence of a complex sensory and regulatory network. PrrA is a …
macrophages is attributed to the presence of a complex sensory and regulatory network. PrrA is a …
Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium …
Mycobacterium tuberculosis (Mtb) employs diverse strategies to survive inside the host
macrophages. In this study, we have identified a conserved hypothetical protein of Mtb; Rv0674, …
macrophages. In this study, we have identified a conserved hypothetical protein of Mtb; Rv0674, …