Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
…, JB McNeil, A Jauregui, S Ke… - The lancet respiratory …, 2022 - thelancet.com
Background Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory
and hypoinflammatory) with distinct clinical and biological features and differential …
and hypoinflammatory) with distinct clinical and biological features and differential …
[HTML][HTML] Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis
…, K Delucchi, T Deiss, T Liu, A Jauregui, S Ke… - Intensive care …, 2020 - Springer
Purpose Previous studies assessing impact of acute respiratory distress syndrome (ARDS)
on mortality have shown conflicting results. We sought to assess the independent association …
on mortality have shown conflicting results. We sought to assess the independent association …
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study
…, C Wang, N Wickersham, JB McNeil, A Jauregui, S Ke… - Thorax, 2022 - thorax.bmj.com
Rationale Using latent class analysis (LCA), two subphenotypes of acute respiratory distress
syndrome (ARDS) have consistently been identified in five randomised controlled trials (…
syndrome (ARDS) have consistently been identified in five randomised controlled trials (…
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients
…, A Gonzalez, K Hiam-Galvez, A Jauregui, S Ke… - Immunity, 2022 - cell.com
While studies have elucidated many pathophysiological elements of COVID-19, little is known
about immunological changes during COVID-19 resolution. We analyzed immune cells …
about immunological changes during COVID-19 resolution. We analyzed immune cells …
[HTML][HTML] Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis
…, DF Choy, H Chen, M Peck, KM Sullivan, S Ke… - Critical Care, 2023 - Springer
Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the
acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels …
acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels …
Peripheral blood leukocyte telomere length is associated with survival of sepsis patients
…, A Gomez, A Jauregui, K Vessel, S Ke… - European …, 2020 - Eur Respiratory Soc
Shorter peripheral blood leukocyte (PBL) telomere length (TL) has been associated with
poor outcomes in various chronic lung diseases. Whether PBL-TL is associated with survival …
poor outcomes in various chronic lung diseases. Whether PBL-TL is associated with survival …
Cigarette smoke exposure and acute respiratory distress syndrome in sepsis: epidemiology, clinical features, and biologic markers
…, H Zhuo, M Arambulo, K Vessel, S Ke… - American journal of …, 2022 - atsjournals.org
Rationale: Cigarette smoke exposure is associated with an increased risk of developing acute
respiratory distress syndrome (ARDS) in trauma, transfusion, and nonpulmonary sepsis. It …
respiratory distress syndrome (ARDS) in trauma, transfusion, and nonpulmonary sepsis. It …
[HTML][HTML] Plasma metabolites in early sepsis identify distinct clusters defined by plasma lipids
…, TJ Deiss, A Belzer, T Liu, M Lippi, S Ke… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: Unbiased global metabolomic profiling has not been used to identify distinct
subclasses in patients with early sepsis and sepsis-associated acute respiratory distress …
subclasses in patients with early sepsis and sepsis-associated acute respiratory distress …
[PDF][PDF] A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
…, G Gordon, PH Serpa, A Jauregui, C Jones, S Ke… - Iscience, 2023 - cell.com
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We
identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from …
identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from …
Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury
…, H Zhuo, K Yee, A Jauregui, S Ke… - American Journal …, 2020 - journals.physiology.org
Sepsis-associated acute kidney injury (AKI) is a complex clinical disorder associated with
inflammation, endothelial dysfunction, and dysregulated coagulation. With standard regression …
inflammation, endothelial dysfunction, and dysregulated coagulation. With standard regression …