Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

…, JB McNeil, A Jauregui, S Ke… - The lancet respiratory …, 2022 - thelancet.com
Background Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory
and hypoinflammatory) with distinct clinical and biological features and differential …

[HTML][HTML] Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis

…, K Delucchi, T Deiss, T Liu, A Jauregui, S Ke… - Intensive care …, 2020 - Springer
Purpose Previous studies assessing impact of acute respiratory distress syndrome (ARDS)
on mortality have shown conflicting results. We sought to assess the independent association …

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study

…, C Wang, N Wickersham, JB McNeil, A Jauregui, S Ke… - Thorax, 2022 - thorax.bmj.com
Rationale Using latent class analysis (LCA), two subphenotypes of acute respiratory distress
syndrome (ARDS) have consistently been identified in five randomised controlled trials (…

Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients

…, A Gonzalez, K Hiam-Galvez, A Jauregui, S Ke… - Immunity, 2022 - cell.com
While studies have elucidated many pathophysiological elements of COVID-19, little is known
about immunological changes during COVID-19 resolution. We analyzed immune cells …

[HTML][HTML] Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis

…, DF Choy, H Chen, M Peck, KM Sullivan, S Ke… - Critical Care, 2023 - Springer
Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the
acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels …

Peripheral blood leukocyte telomere length is associated with survival of sepsis patients

…, A Gomez, A Jauregui, K Vessel, S Ke… - European …, 2020 - Eur Respiratory Soc
Shorter peripheral blood leukocyte (PBL) telomere length (TL) has been associated with
poor outcomes in various chronic lung diseases. Whether PBL-TL is associated with survival …

Cigarette smoke exposure and acute respiratory distress syndrome in sepsis: epidemiology, clinical features, and biologic markers

…, H Zhuo, M Arambulo, K Vessel, S Ke… - American journal of …, 2022 - atsjournals.org
Rationale: Cigarette smoke exposure is associated with an increased risk of developing acute
respiratory distress syndrome (ARDS) in trauma, transfusion, and nonpulmonary sepsis. It …

[HTML][HTML] Plasma metabolites in early sepsis identify distinct clusters defined by plasma lipids

…, TJ Deiss, A Belzer, T Liu, M Lippi, S Ke… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: Unbiased global metabolomic profiling has not been used to identify distinct
subclasses in patients with early sepsis and sepsis-associated acute respiratory distress …

[PDF][PDF] A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

…, G Gordon, PH Serpa, A Jauregui, C Jones, S Ke… - Iscience, 2023 - cell.com
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We
identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from …

Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury

…, H Zhuo, K Yee, A Jauregui, S Ke… - American Journal …, 2020 - journals.physiology.org
Sepsis-associated acute kidney injury (AKI) is a complex clinical disorder associated with
inflammation, endothelial dysfunction, and dysregulated coagulation. With standard regression …