User profiles for Sebastian L. Johnston
Sebastian L JohnstonProfessor of Respiratory Medicine & Allergy, Imperial College London Verified email at imperial.ac.uk Cited by 72662 |
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
SL Johnston, PK Pattemore, G Sanderson, S Smith… - Bmj, 1995 - bmj.com
Objective: To study the association between upper and lower respiratory viral infections and
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are
major causes of health care costs mostly related to hospitalization. The role of infections in …
major causes of health care costs mostly related to hospitalization. The role of infections in …
Role of deficient type III interferon-λ production in asthma exacerbations
…, DE Davies, SV Kotenko, A Papi, SL Johnston - Nature medicine, 2006 - nature.com
… in and are consultants for, and Sebastian L. Johnston is a consultant for Synairgen PLC,
which has an interest in developing interferons for treating respiratory diseases. Sebastian L. …
which has an interest in developing interferons for treating respiratory diseases. Sebastian L. …
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects
are more susceptible to these infections. To investigate the underlying mechanisms of this …
are more susceptible to these infections. To investigate the underlying mechanisms of this …
Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
…, TW Meade, DJ Jeffries, SL Johnston… - American journal of …, 2001 - atsjournals.org
The effects of respiratory viral infection on the time course of chronic obstructive pulmonary
disease (COPD) exacerbation were examined by monitoring changes in systemic …
disease (COPD) exacerbation were examined by monitoring changes in systemic …
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous
with respect to inflammation and etiology. Objectives: Investigate biomarker expression …
with respect to inflammation and etiology. Objectives: Investigate biomarker expression …
[HTML][HTML] The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
…, E Hollams, YA Bochkov, K Grindle, SL Johnston… - Cell host & …, 2015 - cell.com
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
…, T Kebadze, V Vohma, PG Holt, SL Johnston… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe lower respiratory infections (LRIs) and atopic sensitization have
been identified as independent risk factors for asthma. OBJECTIVE: The nature of potential …
been identified as independent risk factors for asthma. OBJECTIVE: The nature of potential …
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis.
SL Johnston, PK Pattemore, G Sanderson… - American journal of …, 1996 - atsjournals.org
We have shown that viruses are associated with 80 to 85% of asthma exacerbations in
school-age children in the community. We hypothesize that viral infections are also associated …
school-age children in the community. We hypothesize that viral infections are also associated …
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
…, J Schreiber, G Sanderson, ST Holgate, SL Johnston - The Lancet, 2002 - thelancet.com
Background Rhinovirus infections cause exacerbations of asthma. We postulated that people
with asthma are more susceptible to rhinovirus infection than people without the disease …
with asthma are more susceptible to rhinovirus infection than people without the disease …