NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
S Kreuz, D Siegmund, P Scheurich… - Molecular and cellular …, 2001 - Am Soc Microbiol
The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of
death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell …
death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell …
[HTML][HTML] Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain
DF Aschauer, S Kreuz, S Rumpel - PloS one, 2013 - journals.plos.org
Recombinant Adeno-associated virus vectors (rAAV) are widely used for gene delivery and
multiple naturally occurring serotypes have been harnessed to target cells in different tissues …
multiple naturally occurring serotypes have been harnessed to target cells in different tissues …
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
S Kreuz, D Siegmund, JJ Rumpf, D Samel… - The Journal of cell …, 2004 - rupress.org
Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-induced
apoptosis are comparably well understood. Here, we show that Fas activates NFκB …
apoptosis are comparably well understood. Here, we show that Fas activates NFκB …
[HTML][HTML] Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain …
…, R Schwenzer, F Mühlenbeck, S Kreuz… - Journal of Biological …, 2000 - ASBMB
In HeLa cells, induction of apoptosis and nuclear factor κB (NF-κB) activation initiated by
TRAIL/Apo2L or the agonistic Apo1/Fas-specific monoclonal antibody anti-APO-1 require the …
TRAIL/Apo2L or the agonistic Apo1/Fas-specific monoclonal antibody anti-APO-1 require the …
Effects of nintedanib on the microvascular architecture in a lung fibrosis model
…, D Schuppan, CD Valenzuela, SJ Mentzer, S Kreuz… - Angiogenesis, 2017 - Springer
Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary
fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the …
fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the …
[HTML][HTML] Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
…, M Romeike, M Schuler, BE Stierstorfer, S Kreuz - Scientific reports, 2017 - nature.com
Extracellular matrix (ECM) composition and stiffness are major driving forces for the development
and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins …
and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins …
[HTML][HTML] Quantification of pulmonary fibrosis in a bleomycin mouse model using automated histological image analysis
JC Gilhodes, Y Julé, S Kreuz, B Stierstorfer, D Stiller… - PloS one, 2017 - journals.plos.org
Current literature on pulmonary fibrosis induced in animal models highlights the need of an
accurate, reliable and reproducible histological quantitative analysis. One of the major limits …
accurate, reliable and reproducible histological quantitative analysis. One of the major limits …
The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function
Aging is accompanied by disrupted information flow, resulting from accumulation of molecular
mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal …
mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal …
[PDF][PDF] Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors
Gene therapies using adeno-associated viruses (AAVs) are among the most promising
strategies to treat or even cure hereditary and acquired retinal diseases. However, the …
strategies to treat or even cure hereditary and acquired retinal diseases. However, the …
[HTML][HTML] Riboswitch-mediated attenuation of transgene cytotoxicity increases adeno-associated virus vector yields in HEK-293 cells
…, B Klauser, JS Hartig, T Lamla, F Gantner, S Kreuz - Molecular Therapy, 2015 - cell.com
Cytotoxicity of transgenes carried by adeno-associated virus (AAV) vectors might be desired,
for instance, in oncolytic virotherapy or occur unexpectedly in exploratory research when …
for instance, in oncolytic virotherapy or occur unexpectedly in exploratory research when …