Effect of helmet noninvasive ventilation vs high-flow nasal oxygen on days free of respiratory support in patients with COVID-19 and moderate to severe hypoxemic …
Importance High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic
respiratory failure and is widely applied in patients with COVID-19. Objective To assess …
respiratory failure and is widely applied in patients with COVID-19. Objective To assess …
Lung-and diaphragm-protective ventilation
…, T Schepens, G Grasselli, S Spadaro… - American journal of …, 2020 - atsjournals.org
Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is
associated with poor clinical outcomes. Although the importance and impact of lung-protective …
associated with poor clinical outcomes. Although the importance and impact of lung-protective …
[HTML][HTML] Oxidative stress and endometriosis: a systematic review of the literature
…, G Bernardi, G Bonaccorsi, S Spadaro… - … medicine and cellular …, 2017 - hindawi.com
Endometriosis is one of the most common gynaecologic diseases in women of reproductive
age. It is characterized by the presence of endometrial tissue outside the uterine cavity. The …
age. It is characterized by the presence of endometrial tissue outside the uterine cavity. The …
[HTML][HTML] Biomarkers for acute respiratory distress syndrome and prospects for personalised medicine
S Spadaro, M Park, C Turrini, T Tunstall… - Journal of …, 2019 - Springer
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality …
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality …
[HTML][HTML] Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients
S Spadaro, A Fogagnolo, G Campo, O Zucchetti… - Critical care, 2021 - Springer
Background Biomarkers can be used to detect the presence of endothelial and/or alveolar
epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion …
epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion …
[HTML][HTML] Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international …
…, E Rezoagli, G Vitale, A Fogagnolo, S Spadaro… - …, 2020 - thelancet.com
Background Coronavirus disease 2019 (COVID-19) is associated with a high disease
burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the …
burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the …
Optimum support by high-flow nasal cannula in acute hypoxemic respiratory failure: effects of increasing flow rates
…, P Taccone, N Bottino, A Lissoni, S Spadaro… - Intensive care …, 2017 - Springer
Purpose Limited data exist on the correlation between higher flow rates of high-flow nasal
cannula (HFNC) and its physiologic effects in patients with acute hypoxemic respiratory failure …
cannula (HFNC) and its physiologic effects in patients with acute hypoxemic respiratory failure …
Estimation of patient's inspiratory effort from the electrical activity of the diaphragm
…, G Grasselli, N Patroniti, S Spadaro… - Critical care …, 2013 - journals.lww.com
Objectives: To calculate an index (termed Pmusc/Eadi index) relating the pressure generated
by the respiratory muscles (Pmusc) to the electrical activity of the diaphragm (Eadi), during …
by the respiratory muscles (Pmusc) to the electrical activity of the diaphragm (Eadi), during …
Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mechanics and transpulmonary pressure during laparoscopic surgery
G Cinnella, S Grasso, S Spadaro… - The Journal of the …, 2013 - pubs.asahq.org
Background: The authors tested the hypothesis that during laparoscopic surgery, Trendelenburg
position and pneumoperitoneum may worsen chest wall elastance, concomitantly …
position and pneumoperitoneum may worsen chest wall elastance, concomitantly …
[HTML][HTML] Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 …
…, R Nicali, VM Ranieri, E Russo, CA Volta, S Spadaro… - Respiratory …, 2021 - Elsevier
Background Health-related quality of life (HRQoL) impairment is often reported among
COVID-19 ICU survivors, and little is known about their long-term outcomes. We evaluated the …
COVID-19 ICU survivors, and little is known about their long-term outcomes. We evaluated the …