We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, however
our understanding of cell specific mechanisms underlying COPD pathobiology remains …

Rationale: Interstitial lung disease (ILD), a leading cause of morbidity and mortality in
rheumatoid arthritis (RA), is highly prevalent, yet RA-ILD is underrecognized. Objectives: To …

Background Epithelial cell death is a major contributor to fibrogenesis in the lung. In this
study, we sought to determine the function of mitochondria and their clearance (mitophagy) in …

Rheumatoid arthritis (RA) is a destructive, systemic, inflammatory disorder that characteristically
affects small, diarthrodial joints in a progressive, symmetric, and erosive fashion. 1 This …

Aging has been implicated in the development of pulmonary fibrosis, which has seen a sharp
increase in incidence in those older than 50 years. Recent studies demonstrate a role for …

The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids,
such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress …

Radiation-induced pulmonary fibrosis is a severe complication of patients treated with
thoracic irradiation. We have previously shown that syndecan-2 reduces fibrosis by exerting …

Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic
effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, …

Altered expression of syndecan-2 (SDC2), a heparan sulfate proteoglycan, has been associated
with diverse types of human cancers. However, the mechanisms by which SDC2 may …