[HTML][HTML] Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary …
…, SRA Wijnant… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …
[HTML][HTML] Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
…, M Obeidat, L Lahousse, SRA Wijnant… - The Lancet …, 2020 - thelancet.com
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects
…, HP Van Eeckhoutte, SRA Wijnant… - European …, 2020 - Eur Respiratory Soc
Angiotensin-converting enzyme 2 (ACE2) has been identified as the cell entry receptor
used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 2]. Importantly, …
used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 2]. Importantly, …
Expression of ACE2, the SARS-CoV-2 receptor, in lung tissue of patients with type 2 diabetes
SRA Wijnant, M Jacobs, HP Van Eeckhoutte… - Diabetes, 2020 - Am Diabetes Assoc
Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to
increased infectivity of COVID-19 in patients with diabetes, but ACE2 expression has not been …
increased infectivity of COVID-19 in patients with diabetes, but ACE2 expression has not been …
[HTML][HTML] Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort
…, A Lee, R Ruiter, BH Stricker, SRA Wijnant… - Genetics in …, 2020 - Elsevier
Purpose We evaluated the performance of the recently extended Breast and Ovarian Analysis
of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch …
of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch …
Frailty transitions in older persons with lung function impairment: a population-based study
SRA Wijnant, E Benz, AI Luik… - The Journals of …, 2023 - academic.oup.com
Background The aging population and its burden on health care systems warrant early
detection of patients at risk of functional decline and mortality. We aimed to assess frailty …
detection of patients at risk of functional decline and mortality. We aimed to assess frailty …
Changes in lung function in European adults born between 1884 and 1996 and implications for the diagnosis of lung disease: a cross-sectional analysis of ten …
…, SAA Vikjord, JM Vonk, SRA Wijnant… - The Lancet …, 2022 - thelancet.com
Background During the past century, socioeconomic and scientific advances have resulted
in changes in the health and physique of European populations. Accompanying …
in changes in the health and physique of European populations. Accompanying …
Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease
Objectives Innate lymphoid cells (ILCs) secrete cytokines, such as IFN‐γ, IL‐13 and IL‐17,
which are linked to chronic obstructive pulmonary disease (COPD). Here, we investigated the …
which are linked to chronic obstructive pulmonary disease (COPD). Here, we investigated the …
[HTML][HTML] Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium
…, HP Van Eeckhoutte, SRA Wijnant… - ERJ open …, 2021 - Eur Respiratory Soc
Increased protein levels of ACE2 in alveolar epithelium of subjects who are homozygous for
the ACE1 insertion of rs1799752 might facilitate host cell entry of# SARSCoV2 and explain …
the ACE1 insertion of rs1799752 might facilitate host cell entry of# SARSCoV2 and explain …
[HTML][HTML] Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study
E Benz, SRA Wijnant, K Trajanoska… - ERJ open …, 2022 - Eur Respiratory Soc
Background Increasing evidence suggests that sarcopenia and a higher systemic immune-inflammation
index (SII) are linked with morbidity in patients with COPD. However, whether …
index (SII) are linked with morbidity in patients with COPD. However, whether …