Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …

Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …

Angiotensin-converting enzyme 2 (ACE2) has been identified as the cell entry receptor
used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 2]. Importantly, …

Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to
increased infectivity of COVID-19 in patients with diabetes, but ACE2 expression has not been …

Purpose We evaluated the performance of the recently extended Breast and Ovarian Analysis
of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch …

Background The aging population and its burden on health care systems warrant early
detection of patients at risk of functional decline and mortality. We aimed to assess frailty …

Background During the past century, socioeconomic and scientific advances have resulted
in changes in the health and physique of European populations. Accompanying …

Objectives Innate lymphoid cells (ILCs) secrete cytokines, such as IFN‐γ, IL‐13 and IL‐17,
which are linked to chronic obstructive pulmonary disease (COPD). Here, we investigated the …

Increased protein levels of ACE2 in alveolar epithelium of subjects who are homozygous for
the ACE1 insertion of rs1799752 might facilitate host cell entry of# SARSCoV2 and explain …

Background Increasing evidence suggests that sarcopenia and a higher systemic immune-inflammation
index (SII) are linked with morbidity in patients with COPD. However, whether …