Cough and airway disease: the role of ion channels
SJ Bonvini, MG Belvisi - Pulmonary pharmacology & therapeutics, 2017 - Elsevier
Cough is the most common reason for patients to visit a primary care physician, yet it
remains an unmet medical need. It can be idiopathic in nature but can also be a troublesome …
remains an unmet medical need. It can be idiopathic in nature but can also be a troublesome …
[HTML][HTML] Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: role of adenosine triphosphate
… Author links open overlay panel Sara J. Bonvini PhD a ∗ , Mark A. Birrell PhD a ∗ , Megan
S. Grace PhD b , Sarah A. Maher PhD a , John J. Adcock PhD a , Michael A. Wortley PhD a , …
S. Grace PhD b , Sarah A. Maher PhD a , John J. Adcock PhD a , Michael A. Wortley PhD a , …
Modulation of the TRPV4 ion channel as a therapeutic target for disease
Transient Receptor Potential Vanilloid 4 (TRPV4) is a broadly expressed, polymodally gated
ion channel that plays an important role in many physiological and pathophysiological …
ion channel that plays an important role in many physiological and pathophysiological …
[HTML][HTML] Mechanistic link between diesel exhaust particles and respiratory reflexes
…, CM McGilvery, S Hu, MSP Shaffer, SJ Bonvini… - Journal of Allergy and …, 2018 - Elsevier
Background Diesel exhaust particles (DEPs) are a major component of particulate matter in
Europe's largest cities, and epidemiologic evidence links exposure with respiratory …
Europe's largest cities, and epidemiologic evidence links exposure with respiratory …
[HTML][HTML] Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?⋆
Background Recent studies have suggested that the long-acting muscarinic receptor antagonist
tiotropium, a drug widely prescribed for its bronchodilator activity in patients with chronic …
tiotropium, a drug widely prescribed for its bronchodilator activity in patients with chronic …
[HTML][HTML] Targeting TRP channels for chronic cough: from bench to bedside
Cough is currently the most common reason for patients to visit a primary care physician in
the UK, yet it remains an unmet medical need. Current therapies have limited efficacy or have …
the UK, yet it remains an unmet medical need. Current therapies have limited efficacy or have …
[HTML][HTML] Novel airway smooth muscle–mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma
SJ Bonvini, MA Birrell, E Dubuis… - European …, 2020 - Eur Respiratory Soc
Mast cell–airway smooth muscle (ASM) interactions play a major role in the immunoglobulin
(Ig)E- dependent bronchoconstriction seen in asthma but less is known about IgE-…
(Ig)E- dependent bronchoconstriction seen in asthma but less is known about IgE-…
Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events
…, MA Wortley, ED Dubuis, SJ Bonvini… - European …, 2015 - Eur Respiratory Soc
Prostaglandin D 2 (PGD 2 ) causes cough and levels are increased in asthma suggesting
that it may contribute to symptoms. Although the prostaglandin D 2 receptor 2 (DP 2 ) is a …
that it may contribute to symptoms. Although the prostaglandin D 2 receptor 2 (DP 2 ) is a …
Novel drug targets for asthma and COPD: lessons learned from in vitro and in vivo models
Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory
diseases characterized by airway inflammation, airway obstruction and airway …
diseases characterized by airway inflammation, airway obstruction and airway …
Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy
Cough is the most common reason to visit a primary care physician, yet it remains an unmet
medical need. Fatty acid amide hydrolase (FAAH) is an enzyme that breaks down …
medical need. Fatty acid amide hydrolase (FAAH) is an enzyme that breaks down …