The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization
and infection. We present an approach to the multi-biome that integrates bacterial, viral …

Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in
humans that is characterized by excessive mobilization of neutrophils into the lung. However, …

The past six decades have seen remarkable improvements in health outcomes for people
with cystic fibrosis, which was once a fatal disease of infants and young children. However, …

Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms of …

Background Women with cystic fibrosis are at increased risk for mucoid conversion of
Pseudomonas aeruginosa, which contributes to a sexual dichotomy in disease severity. Methods …

European Respiratory Society guidelines for the management of adult bronchiectasis highlight
the paucity of treatment options available for patients with this disorder. No treatments …

Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to
first-line azole antifungal drugs. However, despite its clinical importance, little is known …

Background The role of Candida albicans in the cystic fibrosis (CF) airway is underexplored.
Considered a colonizer, few question its pathogenic potential despite high isolation …

Cystic fibrosis (CF) is one of the most common lethal genetic diseases in which the role of
microRNAs has yet to be explored. Predicted to be regulated by miR-126, TOM1 (target of …