Comparison of two interferon-γ assays and tuberculin skin test for tracing tuberculosis contacts

SM Arend, SFT Thijsen, EMS Leyten… - American journal of …, 2007 - atsjournals.org
Background: The tuberculin skin test (TST) has low specificity. QuantiFERON-TB Gold (QFT-G)
and T-SPOT.TB are based on interferon (IFN)-γ responses to Mycobacterium tuberculosis…

[HTML][HTML] Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis

…, K Weldingh, P Andersen, GK Schoolnik, SM Arend… - Microbes and …, 2006 - Elsevier
The dormancy (DosR) regulon of Mycobacterium tuberculosis is expressed in vitro during
hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these …

The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement

D Bumbacea, SM Arend, F Eyuboglu… - European …, 2012 - Eur Respiratory Soc
Tuberculosis (TB) is a possible complication of solid organ and hematopoietic stem cell
transplantation. The identification of candidates for preventive chemotherapy is an effective …

Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10

SM Arend, P Andersen… - The Journal of …, 2000 - academic.oup.com
The purified protein derivative (PPD) skin test has no predictive value for tuberculosis (TB) in
Mycobacterium bovis bacillus Calmette-Guérin (BCG)—vaccinated individuals because of …

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers

JT van Dissel, SM Arend, C Prins, P Bang, PN Tingskov… - Vaccine, 2010 - Elsevier
Though widely used, the BCG vaccine has had little apparent effect on rates of adult pulmonary
tuberculosis. Moreover, the risk of disseminated BCG disease in immunocompromised …

Recognition of Stage-Specific Mycobacterial Antigens Differentiates between Acute and Latent Infections with Mycobacterium tuberculosis

…, G Rook, A Zumla, SM Arend, M Klein… - Clinical and vaccine …, 2006 - Am Soc Microbiol
Mycobacterium tuberculosis is estimated to infect 80 to 100 million people annually, the
majority of whom do not develop clinical tuberculosis (TB) but instead maintain the infection in a …

Antigenic Equivalence of Human T-Cell Responses toMycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 …

SM Arend, A Geluk, KE van Meijgaarden… - Infection and …, 2000 - Am Soc Microbiol
The early secreted antigenic target 6-kDa protein (ESAT-6) and culture filtrate protein 10 (CFP-10)
are promising antigens for reliable immunodiagnosis of tuberculosis. Both antigens …

Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts

…, M Kamphorst, SM Arend… - European …, 2010 - Eur Respiratory Soc
The authors determined the positive predictive value (PPV) for progression to tuberculosis (TB)
of two interferon-γ release assays (IGRAs), QuantiFERON-TB® Gold In-tube (QFT-GIT) …

Epitope Mapping of the Immunodominant Antigen TB10.4 and the Two Homologous Proteins TB10.3 and TB12.9, Which Constitute a Subfamily of the esat-6 Gene …

…, I Brock, SM Arend, ME Munk, M Theisen… - Infection and …, 2002 - Am Soc Microbiol
The human T-cell recognition of the low-molecular-mass culture filtrate antigen TB10.4 was
evaluated in detail. The molecule was strongly recognized by T cells isolated from …

Tuberculin Skin Testing and In Vitro T Cell Responses to ESAT-6 and Culture Filtrate Protein 10 after Infection with Mycobacterium marinum or M. kansasii

SM Arend, KE van Meijgaarden… - The Journal of …, 2002 - academic.oup.com
T cell responses to ESAT-6 and culture filtrate protein 10 (CFP-10), antigens expressed by
Mycobacterium tuberculosis but not by M. bovis bacille Calmette-Guérin (BCG), were found to …