Proteins of the ATP-binding cassette superfamily, mainly P-glycoprotein (P-gp; MDR1), play
an important role in the development of multidrug resistance (MDR) in cancer cells and thus …

We determined the ability of some phytochemicals, including alkaloids (glaucine, harmine,
and sanguinarine), phenolics (EGCG and thymol), and terpenoids (menthol, aromadendrene, …

The composition of essential oils of Chrysanthemum indicum and C. morifolium were
comparatively studied using both Gas Chromatography/Flame ionization Detector (GC/FID) and …

Background Multidrug resistance (MDR) causes failure of doxorubicin therapy of cancer
cells, which develops after or during doxorubicin treatment resulting in cross-resistance to …

Sage, Salvia officinalis L., is used worldwide as an aromatic herb for culinary purposes as
well as a traditional medicinal agent for various ailments. Current investigations exhibited the …

Plant secondary metabolites (SMs) common natural occurrences and the significantly lower
toxicities of many SM have led to the approaching development and use of these …

In phytotherapy, extracts from medicinal plants are employed which contain mixtures of
secondary metabolites. Their modes of action are complex because the secondary metabolites …

Objectives This study aimed to evaluate the variations of the chemical composition and
bioactivity of essential oils of Liquidambar styraciflua L. (Altingiaceae) collected in different …

Multidrug resistance (MDR) is a critical problem in cancer chemotherapy. Cancer cells can
develop resistance not only to a single cytotoxic drug, but also to entire classes of structurally …

P-glycoprotein (P-gp or MDR1) is an ATP-binding cassette (ABC) transporter. It is involved
in the efflux of several anticancer drugs, which leads to chemotherapy failure and multidrug …