[HTML][HTML] Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components
S Vierkotten, PS Muether, S Fauser - PloS one, 2011 - journals.plos.org
Variants in the chromosomal region 10q26 are strongly associated with an increased risk
for age-related macular degeneration (AMD). Two potential AMD genes are located in this …
for age-related macular degeneration (AMD). Two potential AMD genes are located in this …
Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures
… Importantly, induction of surfactant protein C significantly correlated with disease stage (per
cent predicted forced expiratory volume in 1 s) in patient-derived 3D-LTCs. …
cent predicted forced expiratory volume in 1 s) in patient-derived 3D-LTCs. …
Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
K Mutze, S Vierkotten, J Milosevic… - Disease models & …, 2015 - journals.biologists.com
The alveolar epithelium represents a major site of tissue destruction during lung injury. It
consists of alveolar epithelial type I (ATI) and type II (ATII) cells. ATII cells are capable of self-…
consists of alveolar epithelial type I (ATI) and type II (ATII) cells. ATII cells are capable of self-…
[HTML][HTML] Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis
…, S Fiedler, S Vierkotten, J Weber, S Klee… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… 12 s at 94 C, 30 s at 50 C, 30 s at 72 C. Primers pairs from Table 1 were used for the amplification
of specific DNA-fragments from the first strand synthesis. Fluorescence intensities were …
of specific DNA-fragments from the first strand synthesis. Fluorescence intensities were …
Upregulation of TGF-ß1 in experimental proliferative vitreoretinopathy is accompanied by epithelial to mesenchymal transition
R Hoerster, PS Muether, S Vierkotten… - Graefe's Archive for …, 2014 - Springer
Background Proliferative vitreoretinopathy (PVR) is characterized by epithelial to mesenchymal
transition (EMT) of retinal pigment epithelium (RPE) cells and consecutive formation of …
transition (EMT) of retinal pigment epithelium (RPE) cells and consecutive formation of …
Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures
…, A Sengupta, S Vierkotten… - … of Physiology-Lung …, 2018 - journals.physiology.org
… Surprisingly, we also observed fibroblasts that were homing to the lung scaffold’s interstitium
as well as fibroblasts that were invading fibrotic areas. To date, the functional nature and …
as well as fibroblasts that were invading fibrotic areas. To date, the functional nature and …
In-vivo and ex-vivo characterization of laser-induced choroidal neovascularization variability in mice
…, S Vierkotten, S Schröder, B Kirchhof, S Fauser - Graefe's Archive for …, 2012 - Springer
Background Retinal argon laser coagulation is an established procedure for induction of
choroidal neovascularization (CNV) in rodents. This study aimed to evaluate the in-vivo and ex-…
choroidal neovascularization (CNV) in rodents. This study aimed to evaluate the in-vivo and ex-…
Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue
G Burgstaller, S Vierkotten, M Lindner… - … of Physiology-Lung …, 2015 - journals.physiology.org
During the last decades, the study of cell behavior was largely accomplished in uncoated or
extracellular matrix (ECM)-coated plastic dishes. To date, considerable cell biological efforts …
extracellular matrix (ECM)-coated plastic dishes. To date, considerable cell biological efforts …
[HTML][HTML] BARD1 mediates TGF-β signaling in pulmonary fibrosis
PA André, CM Prêle, S Vierkotten, S Carnesecchi… - Respiratory …, 2015 - Springer
… Bound to BRCA1, BARD1 is essential for BRCA1’s E3 ubiquitin ligase and tumor suppressor
activity in DNA repair and cell cycle control [15]. Independently of BRCA1, BARD1 is an …
activity in DNA repair and cell cycle control [15]. Independently of BRCA1, BARD1 is an …
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice
…, F Bengsch, G Martin, H Han, S Vierkotten… - Experimental Eye …, 2013 - Elsevier
Cysteine cathepsins are a family of proteases involved in intracellular protein turnover and
extracellular matrix degradation. Cathepsin B (Ctsb) and cathepsin Z (Ctsz) promote …
extracellular matrix degradation. Cathepsin B (Ctsb) and cathepsin Z (Ctsz) promote …