User profiles for S. Pattenden

Samantha G Pattenden

Associate Professor, University of North Carolina at Chapel Hill
Verified email at unc.edu
Cited by 3343

Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure

S Pattenden, T Antova, M Neuberger… - Tobacco …, 2006 - tobaccocontrol.bmj.com
Objectives: Adverse effects have been reported of prenatal and/or postnatal passive exposure
to smoking on children’s health. Uncertainties remain about the relative importance of …

International study of temperature, heat and urban mortality: the 'ISOTHURM'project

…, RS Kovats, S Pattenden, S Hajat… - International journal …, 2008 - academic.oup.com
Background This study describes heat- and cold-related mortality in 12 urban populations in
low- and middle-income countries, thereby extending knowledge of how diverse populations…

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

…, X Huang, CD Simpson, SG Pattenden… - Nature chemical …, 2011 - nature.com
… Protein lysine methyltransferases (PKMTs) catalyze the transfer of a methyl group from S-adenosyl-L-methionine
(SAM) to the ɛ-amino group of lysine residues of proteins, including …

An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1

…, M Rougie, A Jiang, SG Pattenden… - ACS chemical …, 2013 - ACS Publications
… However, it is not clear how the structural changes contribute to the switch from GSK126’s
high EZH2/EZH1 selectivity (>150-fold) to UNC1999’s low EZH2/EZH1 selectivity (…

Vulnerability to winter mortality in elderly people in Britain: population based study

P Wilkinson, S Pattenden, B Armstrong, A Fletcher… - Bmj, 2004 - bmj.com
Objective To examine the determinants of vulnerability to winter mortality in elderly British
people. Design Population based cohort study (119 389 person years of follow up). Setting …

Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling

B Li, SG Pattenden, D Lee, J Gutiérrez… - Proceedings of the …, 2005 - National Acad Sciences
The yeast histone variant H2AZ (Htz1) is implicated in transcription activation, prevention of
the ectopic spread of heterochromatin, and genome integrity. Our genome-wide localization …

Mortality and temperature in Sofia and London

S Pattenden, B Nikiforov, BG Armstrong - Journal of Epidemiology & …, 2003 - jech.bmj.com
Study objective: Heat and cold have been associated with increased mortality, independently
of seasonal trends, but details are little known. This study explores associations between …

Parental smoking and lung function in children: an international study

…, U Gehring, F Hruba, S Pattenden… - American journal of …, 2006 - atsjournals.org
… symptoms is reported separately (S. Pattenden and colleagues, unpublished data). … (18),
except for minimum exhalation time of 6 s (not feasible for children) and except for the Dutch …

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

…, T Parton, KD Konze, SG Pattenden… - Blood, The Journal …, 2015 - ashpublications.org
Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote
tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases …

Cold comfort: The social and environmental determinants of excess winter deaths in England, 1986-96

…, M Landon, B Armstrong, S Stevenson, S Pattenden… - 2006 - policycommons.net
The nature of the study means that misclassifcation of the temperature characteristics of
dwellings is inevitable, and this is likely to lead to underestimation of the influence of home …