The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

…, M Yoda, Y Nakano, K Tobe, R Nagai, S Kimura… - Nature medicine, 2001 - nature.com
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a
susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where …

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

…, P Froguel, F Foufelle, P Ferre, D Carling, S Kimura… - Nature medicine, 2002 - nature.com
Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis
and glucose and lipid metabolism. However, the signaling pathways that mediate the …

[HTML][HTML] Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6: 6: 1 molar ratio

S Inoue, K Tanaka, F Arisaka, S Kimura… - Journal of Biological …, 2000 - ASBMB
… For integrity of the elementary unit, hydrophobic interactions of P25 with H-chain(s) and
interactions between H-chain(s) and N-linked oligosaccharide chains of P25 were suggested to …

Enzymatic polymerization

S Kobayashi, H Uyama, S Kimura - Chemical reviews, 2001 - ACS Publications
… Poly(hydroxyalkanoate)s (PHA)s are commercially produced as biodegradable plastics.
In the biosynthetic pathways of PHA, the last step is the chain growth polymerization of …

Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies

Y Fu, S Yang, SH Jeong, S Kimura… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
… For example, the solubility, crystal morphology, particle size, hygroscopicity, compressibility,
and bulk density of a drug can significantly affect the final tablet’s characteristics, such as …

Enzymes as green catalysts for precision macromolecular synthesis

S Shoda, H Uyama, J Kadokawa, S Kimura… - Chemical …, 2016 - ACS Publications
… The conductivity of the polyaniline/SPS complex was measured to be 0.005 S/cm. The
value increased to 0.15 S/cm with HCl doping. The enzymatic approach is claimed to offer …

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

M Yanagisawa, H Kurihara, S Kimura, Y Tomobe… - nature, 1988 - nature.com
… short-lived endothelium-derived relaxing factor(s) (EDRF), causing relaxation of underlying
… Diffusible factor(s) which mediate these constrictive reactions have yet to be identified. …

[PDF][PDF] PPARγ mediates high-fat diet–induced adipocyte hypertrophy and insulin resistance

…, O Ezaki, S Aizawa, R Nagai, K Tobe, S Kimura… - Molecular cell, 1999 - cell.com
Agonist-induced activation of peroxisome proliferator-activated receptor γ (PPARγ) is known
to cause adipocyte differentiation and insulin sensitivity. The biological role of PPARγ was …

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

A Inoue, M Yanagisawa, S Kimura… - Proceedings of the …, 1989 - National Acad Sciences
… In search of the possible existence of endothelin-related peptide(s) at the DNA level, we
have encountered three distinct human genes for putative endothelin precursors. Interestingly, …

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

…, M Yanagisawa, Y Takuwat, H Miyazakit, S Kimura… - Nature, 1990 - nature.com
… component appeared abruptly, reached a peak within 0.5 s and then rapidly decayed (Fig.
1 ac); it occurred while there was little or no change in average [Ca“"], (Fig. 1a-c). …