… Lag time should be <5 s and rise time <2 s, giving a total response time of <7 s. Lag … s [38].
It is recommended that the inspiration is rapid (no longer than 2.5 s in healthy subjects and 4 s …

… to form S-nitrosoproteins and S-nitrosothiols (29). Approximately 70 to 90% of NO is
released by S-nitrosothiols, which therefore provide a major source of NO in tissues (30). S-…

… percentage improvement in the forced expiratory volume in 1 s (FEV1) from baseline to the
post… (Kharitonov et al. 1996a) or within 2±3days after inhaled corticosteroids (Kharitonov et al. …

… manoeuvre over 30-75 s into wide-bore … s. Since there was no change in NO concentration
before and after inhalation, inspired NO must disappear from the respiratory tract within 15 s. …

… not be sensitive were previously diagnosed by a physician as S Lim enough to reflect the
extent of airway inflam- having asthma, had BHR to methacholine proSA Kharitonov mation. …

… S. Kharitonov and PJ Barnes, unpublished observations). The fact that inhaled glucocorticoids
reduce exhaled NO may provide further support for a lower airway origin of exhaled NO in …

… All the patients had airways obstruction with forced expiratory volume in 1 s (FEV 1 ) < 80%
predicted and forced expiratory volume in 1 s/forced vital capacity (FEV 1 /FVC) ratio < 70%, …

… Measurements of exhaled NO were made by slow exhalation (5 to 6 L/min) from TLC for
20 to 30 s against a resistance (3 ± 0.4 mm Hg), to prevent nasal contamination. …

… We have previously shown that inhalation of NO with a breath hold of 15 s causes no increase
in the concentration of exhaled NO. We have also demonstrated that the NOS inhibitor NG…

… Subjects were asked to produce a slow vital capacity manoeuvre over 30–45 s into wide-bore
Teflon tubing. NO was sampled continuously. The baseline value at each visit was …